黄国伟，教授，博士生导师

简历

研究方向

近年来的主要研究方向是：营养与疾病，营养与神经科学。

学习经历

1. 1981～1986，天津医科大学，预防医学，学士学位

2. 1986～1989，天津医科大学，营养与食品卫生学，硕士学位

3. 2005～2009，天津科技大学，食品科学，博士学位

工作经历

1. 2018.04至今天津医科大学营养与食品卫生学系教授，系主任

2. 2005～2018 天津医科大学营养与食品卫生学教研室系教授，系主任，院长

3. 2003～2004 加拿大西安大略大学医学院客座教授

4. 2000～2005 天津医科大学公共卫生学院营养研究室教授，副院长

5. 1995～2000 天津医科大学公共卫生学院营养研究室副教授

6. 1989～1995 天津医科大学公共卫生学院营养与食品卫生学教研室助教、讲师

主要承担或参与的课题

1. 国家自然科学基金重点项目“基于端粒叶酸对神经细胞凋亡及延缓老年人认知减退的作用及机制研究”，项目编号：81730091，2018.1-2022.12，资助经费：300万元，在研，主持。

2. 汤臣倍健营养科学研究基金项目“叶酸和DHA联合应用对轻度认知功能障碍老年人干预作用的研究”，项目编号：TY0151102，2016.1-2019.6，资助经费：35万元，在研，主持。

3. 天津市科技支撑重点项目“以社区为基础叶酸、维生素B12联合防治阿尔茨海默病干预技术研究”，项目编号：15ZCZDSY01040，2015.10-2018.9，资助经费：30万元，已经结题，主持。

4. 国家自然科学基金面上项目“叶酸通过DNA甲基化途径对脑发育表观遗传学作用机制的研究”，项目编号：81472967，2015.1-2018.12，资助经费：90万元，已经结题，主持。

5. 国家自然科学基金重点项目“基于DNA甲基化途径叶酸对阿尔茨海默病作用机制的研究”，项目编号：81130053，2012.1-2016.12，资助经费：260万元，已经结题，主持。

6. 国家自然科学基金面上项目“基于DNA甲基化的叶酸对神经干细胞表观遗传学作用机制的研究”，项目编号：81072289，2011.1-2013.12，资助经费：33万元，已经结题，主持。

7. 国家自然科学基金面上项目“叶酸对神经干细胞增殖分化作用蛋白质组学的研究”，项目编号：30771797，2008.1-2010.12，资助经费：30万元，已经结题，主持。

8. 国家自然科学基金面上项目“叶酸对神经干细胞增殖分化调控机制的研究”，项目编号：30571563，2006.1-2008.12，资助经费：26万元，已经结题，主持。

9. 国家科技支撑计划项目“我国居民肥胖与2型糖尿病早期干预及防治措施的研究”（子项目），项目编号：2012BAI02B02，2012.1-2015.12，资助经费：95万元，已经结题，主持。

10. 达能膳食营养研究与宣教基金项目“人群膳食因素与高尿酸血症及代谢综合征关系的研究”，项目编号：DIC2008-01，2009.1-2010.12，资助经费：20万元，已经结题，主持。

11. 天津市应用基础与前沿技术研究计划重点项目“代谢综合征人群膳食干预防治技术的研究”，项目编号：10JCZDJC18700，2010.4-2012.12，20万元，已经结题，主持。

近五年发表文章（*为通讯作者）

1. Xinyan Wang, Wen Li, Zhenshu Li, Yue Ma, Jing Yan, John X. Wilson and Guowei Huang*. Maternal Folic Acid Supplementation During Pregnancy Promotes Neurogenesis and Synaptogenesis in Neonatal Rat Offspring. Cerebral Cortex. 2018 Aug 23. doi: 10.1093/cercor/bhy207. [Epub ahead of print].

2. Shanshan Cui, Xin Lv, Wen Li, Zhenshu Li, Huan Liu, Yuxia Gao*, Guowei Huang*. Folic acid modulates VPO1 DNA methylation levels and alleviates oxidative stress-induced apoptosis in vivo and in vitro. Redox Biology. 2018 Aug 8; 19:81-91.

3. Xinyan Wang, Wen Li, Shou Li, Jing Yan, John X. Wilson, Guowei Huang*. Maternal Folic Acid Supplementation During Pregnancy Improves Neurobehavioral Development in Rat Offspring. Mol Neurobiol. 2018, Mar 9, 55(3), 2676-2684.

4. Wen Li, Zhenshu Li, Shou Li, Xinyan Wang, John X. Wilson, Guowei Huang*. Periconceptional Folic Acid Supplementation Benefit to Development of Early Sensory-Motor Function through Increase DNA Methylation in Rat Offspring. Nutrients. 2018, 10(3), 292.

5. Ma F, Li Q, Zhou X, Zhao J, Song A, Li W, Liu H, Xu W, Huang G*. Effects of folic acid supplementation on cognitive function and Aβ-related biomarkers in mild cognitive impairment: a randomized controlled trial. Eur J Nutr. 2017 Dec 18. doi: 10.1007/s00394-017-1598-5. [Epub ahead of print]

6. Jing Yan, Yuyan Liu, Lujia Cao, Yuzhi Zheng, Wen Li, Guowei Huang*. Association between Duration of Maternal Folic Acid Supplementation and Postpartum Depression. Nutrients. 2017 Nov 2;9(11). pii: E1206.

7. Fei Ma, Tianfeng Wu, Jiangang Zhao, Lu Ji, Aili Song, Meilin Zhang, Guowei Huang*. Plasma Homocysteine and Serum Folate and Vitamin B12 Levels in Mild Cognitive Impairment and Alzheimer’s disease: A Case-control Study. Nutrients. 2017 Jul 8;9(7). pii: E725.

8. Shanshan Cui, Wen Li, Xin Lv, Pengyan Wang, Yuxia Gao*, Guowei Huang*. Folic Acid Supplementation Delays Atherosclerotic Lesion Development by Modulating MCP1 and VEGF DNA Methylation Levels In Vivo and In Vitro. Intl J Mol Sci. 2017 May 5;18(5): 990.

9. Fei Ma, Tianfeng Wu, Jiangang Zhao, Fengmei Han, Anna Marseglia, Huan Liu, Guowei Huang*. Effects of six-month folic acid supplementation on cognitive function and blood biomarkers in Mild Cognitive Impairment: a randomized controlled trial in China. J Gerontol A Biol Sci Med Sci. 2016 Oct;71(10):1376-83.

10. Wen Li, Huan Liu, Min Yua, Xumei Zhanga, Yan Zhangb, Hongbo Liub, John X. Wilsonc, Guowei Huang*. Folic acid alters methylation profile of JAK-STAT and long-term depression signaling pathways in Alzheimer's disease models. Mol Neurobiol. 2016 Nov;53(9):6548-6556.

11. Meilin Zhang, Li Zheng, Ping Li, Yufeng Zhu, Hong Chang, Xuan Wang, Weiqiao Liu, Yuwen Zhang, Guowei Huang*. 4-year trajectory of visceral adiposity index in the development of type 2 diabetes: a prospective cohort study. Ann Nutr Metab 2016;69:142-149.

12. Xuan Wang, Mingyue Zhang, Guang Lui, Hong Chang, Meilin Zhang, Wei Liu, Ziwei Li, Yixin Liu, Guowei Huang*. Associations of Serum Manganese Levels with Prediabetes and Diabetes among ≥60-Year-Old Chinese Adults: A Population-Based Cross-Sectional Analysis. Nutrients, 2016 Aug 13;8(8). pii: E497.

13. Hui Chen, Shuai Liu, Lu Ji, Tianfeng Wu, Yong Ji, Yuying Zhou, Miaoyan Zheng, Meilin Zhang, Weili Xu, Guowei Huang*. Folic acid supplementation mitigates Alzheimer’s disease by reducing inflammation: a randomized controlled trial. Mediators Inflamm. 2016;2016:5912146.

14. Huan Liu, Wen Li, Shijing Zhao, Xumei Zhang, Meilin Zhang, Yanyu Xiao, John X. Wilson, Guowei Huang*. Folic acid attenuates the effects of amyloid β oligomers on DNA methylation in neuronal cells. Eur J Nutr. 2016 Aug;55(5):1849-62.

15. Meilin Zhang, Ping Li, Yufeng Zhu, Hong Chang, Xuan Wang, Weiqiao Liu, Yuwen Zhang, Guowei Huang*. Higher visceral fat area increases the risk of vitamin D insufficiency and deficiency in Chinese adults. Nutrition & Metabolism. 2015 Nov 25;12:50.

16. Wen Li, Mingyue Jiang, Shijing Zhao, Huan Liu, Xumei Zhang, John X Wilson, Guowei Huang*. Folic Acid Inhibits Amyloid β-Peptide Production through Modulating DNA Methyltransferase Activity in N2a-APP Cells. Intl J Mol Sci. 2015 Oct 20, 16, 25002-25013.

17. Meilin Zhang, Yufeng Zhu, Ping Li, Hong Chang, Xuan Wang, Weiqiao Liu, Yuwen Zhang, Guowei Huang*. Associations between Dietary Patterns and Impaired Fasting Glucose in Chinese Men: A Cross-Sectional Study. Nutrients. 2015 Sep 21;7(9):8072-89.

18. Huan Liu, Tian Tian, Shanchun Qin, Wen Li, Xumei Zhang, Xuan Wang, Yuxia Gao, Guowei Huang*. Folic acid deficiency enhances abeta accumulation in APP/PS1 mice brain and decreases amyloid-associated miRNAs expression. J Nutr Biochem. 2015 Dec; 26(12):1502-8.

19. Wen Li, Huan Liu, Min Yu, Xumei Zhang, Meilin Zhang, John X. Wilson, Guowei Huang*. Folic acid administration inhibits amyloid β-peptide accumulation in APP/PS1 transgenic mice. J Nutr Biochem. 2015 Aug, 26(8):883-891. （IF: 4.414，5-years IF: 4.669）

20. Hui Chen, Shuai Liu, Lu Ji, Tianfeng Wu, Fei Ma, Yong Ji, Yuying Zhou, Miaoyan Zheng, Meilin Zhang, Guowei Huang*. Associations between Alzheimer’s Disease and Blood Homocysteine, Vitamin B12, and Folate: A Case-Control Study. Curr Alzheimer Res. 2015, 12(1):88-94.

21. Fei Ma, Tianfeng Wu, Rujuan Miao, Yan yu Xiao, Wenwen Zhang, Guowei Huang*. Conversion of Mild Cognitive Impairment to Dementia among Subjects with Diabetes: a Population-based Study of Incidence and Risk Factors with Five Years of Follow-up. J Alzheimers Dis. 2015,43(4):1441-1449.

22. Wen Li, Mingyue Jiang, Yanyu Xiao, Xumei Zhang, Shanshan Cui, Guowei Huang*. Folic acid inhibits tau phosphorylation through regulation of PP2A methylation in SH-SY5Y cells. J Nutr Health Aging. 2015 Feb;19(2):123-9.

23. Jing Yan, Lin Liu, Yun Zhu, Guowei Huang*, Peizhong Peter Wang*. The association between breastfeeding and childhood obesity: a meta-analysis. BMC Public Health 2014, 14:1267.

研究生培养情况

博士生毕业9名，在职5名

硕士生毕业40名，在职8名

招生专业

营养与食品卫生学

社会兼职

1. 教育部高等学校公共卫生与预防医学类专业教学指导委员会委员

2. 中国营养学会常务理事

3. 天津市营养学会副理事长

4. 中华预防医学会公共卫生教育分会第四届常务委员