Run-Ling Wang, Professor
发布人:药学院-英文  发布时间:2019-12-05   浏览次数:118

 


Run-Ling Wang, Ph.D.

 


Run-Ling Wang, PhD

Professor 

School of pharmacy

Tianjin Medical University 

22 Qixiangtai Road

Tianjin 300070

Phone+86-83336690

Email: wangrunling@tmu.edu.cn

 

Education

MD     Peking University Health Science CenterBeijing, China, 1982

Ph.D.  Tianjin University, Tianjin, China, 2006

 

Professional Experience

1982.07-1984.09       Assistant, Department of Pharmacy, Tianjin Medical University, Tianjin, China

1984.10-1994.09       InstructorDepartment of Pharmacy, Tianjin Medical University, Tianjin, China

1994.10-1999.09       Associate Professor, Department of Pharmacy, Tianjin Medical University, Tianjin, China

1999.10-2015.04       Associate dean, Professor, Department of Pharmacy, Tianjin Medical University, Tianjin, China

2015.5-                      Professor, Department of Pharmacy, Tianjin Medical University, Tianjin, China


Honors

2016, The Ninth Tianjin Teachers' College Teaching Award;

2009, Tianjin outstanding teachers;

2009, The second prize of Tianjin Municipal Teaching Achievement Award of Higher Education in The Reform and Practice of Practice Teaching in Pharmacy;

2008, The major award of Teaching Achievements of Tianjin Medical University;

2013, The Excellent Teaching Instructor Award for Tianjin University Students Extracurricular Academic Work Competition in the Twelfth Challenge Cup;

2003, Presided over the development of arginine ibuprofen and its syrup, won the third prize of Tianjin Science and Technology Progress;

1997, Presided over the ibuprofen syrup bioavailability study project, won the Tianjin Municipal Health Bureau third prize for progress of science and technology;

2003, The honorary of advanced individual in Tianjin 10th Five-Year Plan;

2001, Presided over the reform of chemistry experiment  and won the Tianjin Municipal Education Commission laboratory construction  individual award.

2006 Tianjin Medical University fifteen advanced individual in science and technology work;

2012 Excellent Instructor of Science and Technology Innovation in Tianjin Medical University;

2002 The Outstanding Contribution Award of Tianjin Medical University in the course of scientific research during the Ninth Five-Year Plan;

The outstanding teachers in Tianjin Medical University in 2002 and 1999.

1997 The outstanding young technician awarded by Tianjin Municipal Health Bureau;

1998-2000 The cross-century talent awarded by the Tianjin Medical University.

 

 

Books

Medicinal Chemistry, editor-in-chief, First edition, 2013.7, The Tsinghua University Press

Medicinal Chemistry, editor-in-chief, Third edition, 2012.5, The Medical Science and Technology Press

Experiment II of Pharmacy chemistry, editor-in-chief, 2008.7, People's Medical Publishing House

Medicinal Chemistry, Cenbian, Seventh edition, 2011.8, People's Medical Publishing House

Medicinal Chemistry, Cenbian, Second edition, 2011.2, China Medical Science and Technology Press

Clinical pharmaceutical chemistry, Editorial Board, 2007.8, People's Medical Publishing House

Modern Drug Design, Editorial Board, 2006, China Medical Science and Technology Press

 

Publication 

1 Jun Zhang, Xin Liu, Shu-Qing Wang, Gui-You Liu, Wei-Ren Xu, Xian-Chao Cheng*, Run-Ling Wang*. Identification of dual ligands targeting angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ by core hopping of telmisartan [J]. Journal of Biomolecular Structure and Dynamics, 2017, 35 (12): 2665–2680

2 Yue-Qin Zheng, Yu-Qing Duan, Kai-Li Ji, Run-Ling Wang*, Bing-He Wang*. Tuning the reaction rates of fluoride probes for detection in aqueous solution [J]. RSC Advances, 2016, 6, 25242–25245

3 Xiao-Bo Li, Lei Dong, Wei-Ren Xu, Soumitra S. Bhuyan, Chenglung Chen, Run-Ling Wang. Study of SHP-2 (PTPN11) allosterism on structural movement using solution perturbed molecular dynamics simulation [J]. Journal of Molecular Liquids, 2016, 223, 509-515

4 Liu-Qing Wen, Lan-Lan Zang, Kenneth Huang, Shan-Shan Li, Run-Ling Wang*, Peng George Wang*. Efficient enzymatic synthesis of L-rhamnulose and L-fuculose [J]. Bioorganic & Medicinal Chemistry Letters, 2016, 26 (3): 969-972

5 Jun Zhang, Xin Liu, Shu-Qing Wang, Gui-You Liu, Wei-Ren Xu, Xian-Chao Cheng *, Run-Ling Wang*. Identification of dual ligands targeting angiotensin II type 1 receptor and peroxisome proliferator activated receptor-γ by core hopping of telmisartan [J]. Journal of Biomolecular Structure and Dynamics, 2016, 7, 1-16

6 Mei-Yan Wang, Yuan-Yuan Jin, Hui-Yu Wei, Li-Song Zhang, Su-Xia Sun, Xiu-Bo Chen, Wei-Li Dong, Wei-Ren Xu, Xian-Chao Cheng*, Run-Ling Wang*. Synthesis, biological evaluation and 3D-QSAR studies of imidazolidine-2,4-dione derivatives as novel protein tyrosine phosphatase 1B inhibitors [J]. European Journal of Medicinal Chemistry, 2015, 103, 91-104

7 Xue-Jiao Wang, Jun Zhang, Shu-Qing Wang, Wei-Ren Xu, Xian-Chao Cheng, Run-Ling Wang*. Identification of novel multitargeted PPARα/γ/δ pan agonists by core hopping of rosiglitazone [J]. Drug Design, Development and Therapy, 2014, 8, 2255-2262       

8 Ying Ma, Yuan-Yuan Jin, Ye-Liu Wang, Run-Ling Wang*, Xin-Hua Lu, De-Xin Kong, Wei-Ren Xu. The Discovery of a Novel and Selective Inhibitor of PTP1B Over TCPTP: 3D-QSAR Pharmacophore Modeling, Virtual Screening, Synthesis, and Biological Evaluation [J]. Chemical Biology & Drug Design, 2014, 83, 697-709 

9 Lan-Lan Zang, Xue-Jiao Wang, Xiao-Bo Li, Shu-Qing Wang, Wei-Ren Xu, Xian-Bin Xie, Xian-Chao Cheng, Huan Ma, Run-Ling Wang*. SAHA-based novel HDAC inhibitor design by core hopping method [J]. Journal of Molecular Graphics and Modelling, 2014, 54, 10-18       

10 Jing-Wei Wu, Huan Zhang, Yu-Qing Duan, Wei-Li Dong, Xian-Chao Cheng, Shu-Qing Wang, Run-Ling Wang*. Design Novel Inhibitors for Treating Cancer by Targeting Cdc25B Catalytic Domain with De Novo Design [J]. Combinatorial chemistry & high throughput screening, 2014, 17(10): 837-847

11 Yu-Qing Duan, Ying Ma, Xue-Jiao Wang, Yuan-Yuan Jin, Run-Ling Wang*, Wei-Li Dong, Wei-Ren Xu, De-Xin Kong, Shu-Qing Wang*. Design Potential Selective Inhibitors for Treating Cancer by Targeting the Src Homology 2 (SH2) Domain-Containing Phosphatase 2 (Shp2) with Core Hopping Approach [J]. Protein & Peptide Letters, 2014, 21(6): 556-563

12 Yuan-Yuan Jin, Ying Ma, Quan-Xiong Gao, Run-Ling Wang*, Shu-Qing Wang, Wei-Ren Xu. Design of specific inhibitors of the protein tyrosine phosphatase SHP-2 by virtual screening and core hopping method [J]. Molecular Simulation, 2014, 40 (12): 904–911

13 Wei-Bing Zhang, Wen-Bo Liu, Jing-Wei Wu, Wei-Li Dong, Shu-Qing Wang*, Run-Ling Wang*. The derivatives of oseltamivir design passing through the important cleft of neuraminidase against influenza virus by de novo design [J]. Molecular Simulation, 2014, 40(15): 1209–1217

14 Ying Ma, Su-Xia Sun, Xian-Chao Cheng, Shu-Qing Wang, Wei-Li Dong, Run-Ling Wang*, Wei-Ren Xu. Design and Synthesis of Imidazolidine-2,4-Dione Derivatives as Selective Inhibitors by Targeting Protein Tyrosine Phosphatase-1B Over T-Cell Protein Tyrosine Phosphatase [J]. Chemical Biology & Drug Design, 2013, 82(5): 595-602 

15 Su-Xia Sun, Xiao-Bo Li, Wen-Bo Liu, Ying Ma, Run-Ling Wang*, Xian-Chao Cheng, Shu-Qing Wang, Wei Liu. Design, Synthesis, Biological Activity and Molecular Dynamics Studies of Specific Protein Tyrosine Phosphatase 1B Inhibitors over SHP-2 [J]. International journal of molecular sciences, 2013, 14, 12661-12674 

16 Lei Liu, Ying Ma, Run-Ling Wang*, Wei-Ren Xu, Shu-Qing Wang*, Kuo-Chen Chou. Find novel dual-agonist drugs for treating type 2 diabetes by means of cheminformatics [J]. Drug Design Development and Therapy, 2013, 7, 279-288  

17 Wen-Ming Li, Xiao-Bo Li, Su-Xia Sun, Jing Liang, Run-Ling Wang*, Shu-Qing Wang. Agonist and antagonist recognition studies for oestrogen receptor by molecular dynamics Simulation [J]. Molecular Simulation, 2013, 39(3):228-233

18 Xian-Chao Cheng, Run-Ling Wang*, Zhen-Ke Dong, Jing Li, Yao-Yuan Li, Rong-Rong Li. Design, synthesis and evaluation of novel metalloproteinase inhibitors based on L-tyrosine scaffold [J]. Bioorganic & Medicinal Chemistry, 2012, 20, 5738–5744 

19 Ying Ma, Shu-Qing Wang*, Wei-Ren Xu, Run-Ling Wang*, Kuo-Chen Chou. Design Novel Dual Agonists for Treating Type-2 Diabetes by Targeting Peroxisome Proliferator-Activated Receptors with Core Hopping Approach [J]. PLoS ONE, 2012, 7(6): e38546

 

Grant

Ongoing

NSFT(16JCZDJC32500),2016/04-2019/03, PI, The research on the selective SHP2 D61GE76K inhibitors;

The International (Regional) Cooperation and Exchange Project of the National Natural Science Foundation of China(81611130090), 2016/01-2018/12, PI, Rational design, synthesis and activity screening of Shp2 inhibitors for treatment of leukemia.

Completed:

NSFC(81273361), 2013/01-2016/12, PI, The research on the selective protein tyrosine phosphatase SHP2 inhibitors;

NSFC(20972112), 2010/01-2012/12, PI, The design, synthesis, and biological study of antidiabetic drugs targeting PTP-1B, PPAR-α and PPAR-γ;

Key project of Tianjin Natural Science Foundation (09JCZDJC21600), 2009/04-2012/03, PI, The research based on the structure of PTP1B enzyme to discover lead antidiabetic drugs;

the Specialized Research Fund for the Doctoral Program of Higher Education of China(20091202110010), 2010/01-2012/12,PI, The design, synthesis, and biological study of antidiabetic drugs targeting PTP-1B, PPAR-α and PPAR-γ.