Xumei Zhang

Professor，PhD

Department of Nutrition and Food Science,

School of Public Health

Tianjin Medical University

No.22 Qixiangtai Road

Tianjin 300070

Phone: +86-22-83336615

Email Address: zhangxumei@tmu.edu.cn

Education （最高学位起 倒序）

1.Postdoctoral Fellow Tianjin Medical University, Tianjin, China, 2017

2.Ph.D. Academy of Military Medical Sciences, Tianjin, China, 2006

3.Sc. Sichuan Agriculture University, Sichuan, China, 2003

4.B.Sc. Liaocheng Teacher’s University, Shandong, China, 1998

Professional Background （最高职称起 倒序）

1.2017- Professor, Tianjin Medical University, Department of Nutrition and Food Science, School of Public Health 

2.2009-2017 Associate Professor, 2015-Department of Nutrition and Food Science, Tianjin Medical University

3.2010-2011 Visiting scholar, John Hopkins University, School of Public Health 

4.2006-2009 Lecturer,Tianjin Medical University, Department of Nutrition and Food Science, School of Public Health

Awards Received 

1.The national model branch of the party building work of the Ministry of Education, 2020; Tianjin Navigation Engineering Party Building Model Branch, 2021.

2.Tianjin's Twelfth Five Year Plan and Thirteenth Five Year Plan include young and middle-aged innovative talents in universities

3.Outstanding Youth Award in Nutrition Science, Chinese Nutrition Society, 2015.

4.Advanced Society Workers of Tianjin Association for Science and Technology,2014.

5.Tianjin Medical University's New Century Excellent Talents, Women's Merit Model (2020), and Excellent Teachers during the 11th Five Year Plan period(2021), Excellent Party Workers (2020), etc.

6.Second Prize of Tianjin Science and Technology Progress Award,2021, ranked 5th

Other Roles

1.Committee Member of the Special Nutrition Branch of the Chinese Nutrition Society

2.Committee Member of the Nutrition and Neuroscience Branch of the Chinese Nutrition Society

3.Vice Secretary-General of Tianjin Nutrition Society

4.Vice Chairman of the Science Popularization Branch of Tianjin Health Education Association

5.Vice Chairman of the Nutrition and Health Promotion Committee of the Tianjin Health Management Association (2nd Session)

Publications（近5年最具代表性的，不多于15篇）

1.Cheng M, Liang X, Shi L, Zhang Q, Zhang L, Gong Z, Luo S, Wang X, Zhang X*. Folic acid deficiency exacerbates the inflammatory response of astrocytes after ischemia-reperfusion by enhancing the interaction between IL-6 and JAK-1/pSTAT3. CNS Neurosci Ther. 2023 Jun;29(6):1537-1546

2.Liang X, Shi L, Wang M, Zhang L, Gong Z, Luo S, Wang X, Zhang Q, Zhang X*. Folic acid ameliorates synaptic impairment following cerebral ischemia/reperfusion injury via inhibiting excessive activation of NMDA receptors. J Nutr Biochem. 2023 Feb;112:109209.

3.Wang M#, Liang X#, Zhang Q, Luo S, Liu H, Wang X, Sai N, Zhang X*. Homocysteine can aggravate depressive like behaviors in a middle cerebral artery occlusion/reperfusion rat model: a possible role for NMDARs-mediated synaptic alterations. Nutr Neurosci. 2022 Apr 13:1-13.

4.Fu M#, Liang X#, Zhang X#, Yang M, Ye Q, Qi Y, Liu H*, Zhang X*. Astaxanthin delays brain aging in senescence-accelerated mouse prone 10: inducing autophagy as a potential mechanism. Nutr Neurosci. 2022 Apr 6:1-11.

5.Yang L#, Ye Q, Zhang X, Li K, Liang X, Wang M, Shi L, Luo S, Zhang Q, Zhang X*. Pyrroloquinoline quinone extends Caenorhabditis elegans' longevity through the insulin/IGF1 signaling pathway-mediated activation of autophagy. Food Funct. 2021 Nov 15;12(22):11319-11330. 

6.Zhang Q#, Zhang X#, Li S, Liu H, Liu L, Huang Q, Hou Y, Liang X, Cui B, Zhang M, Xia L, Zhang L, Li C, Li J, Sun G, Tang N#. Joint effect of urinary arsenic species and serum one-carbon metabolism nutrients on gestational diabetes mellitus: A cross-sectional study of Chinese pregnant women. Environ Int. 2021 Jun 30;156:106741.

7.Gou Yun, Ye Qi, Liang Xiaoshan, Zhang Qiang, Luo Suhui, Liu Huan, Wang Xuan, Sai Na, Zhang Xumei*. Homocysteine restrains hippocampal neurogenesis in focal ischemic rat brain by inhibiting DNA methylation. Neurochemistry international. 2021 Jul;147:105065.

8.Dong Z#, Liang X, Zhang Q, Luo S, Liu H, Wang X, Sai N, Zhang X*. Folic acid deficiency enhances the Tyr705 and Ser727 phosphorylation of mitochondrial STAT3 in In Vivo and In Vitro models of ischemic stroke. Transl Stroke Res. 2021 Oct;12(5):829-843.

9.Min Fu#, Xumei Zhang#, Xuguang Zhang#, Liu Yang, Suhui Luo, Huan Liu*. Autophagy Plays a Role in the Prolongation of the Life Span of Caenorhabditis elegans by Astaxanthin. Rejuvenation Res.  2021 Jun;24(3):198-205.

10.Sun Y#, Cheng M, Liang X, Chen S, Wang M, Zhang X*. JAK2/STAT3 involves oxidative stress-induced cell injury in N2a cells and a rat MCAO model. Int J Neurosci. 2020 Nov;130(11):1142-1150

11.Wang M#, Liang X, Cheng M, Yang L, Liu H, Wang X, Sai N, Zhang X*. Homocysteine enhances neural stem cell autophagy in in vivo and in vitro model of ischemic stroke, Cell Death Dis, 2019 Jul 22; 10(8):561.

12.Cheng M#, Yang L, Dong Z, Wang M, Sun Y, Liu H, Wang X, Sai N, Huang G, Zhang X*. Folic acid deficiency enhanced microglial immune response via the Notch1/nuclear factor kappa B p65 pathway in hippocampus following rat brain I/R injury and BV2 cells. J Cell Mol Med. 2019 Jul;23(7):4795-4807. 

13.Chen S#, Dong Z, Cheng M, Zhao Y, Wang M, Sai N, Wang X, Liu H, Huang G, Zhang X*. Homocysteine exaggerates microglia activation and neuroinflammation through microglia localized STAT3 overactivation following ischemic stroke. J Neuroinflammation. 2017 Sep 18;14(1):187. 

14.Chen S#, Dong Z, Zhao Y, Sai N, Wang X, Liu H, Huang G, Zhang X*. Homocysteine induces mitochondrial dysfunction involving the crosstalk between oxidative stress and mitochondrial pSTAT3 in rat ischemic brain. Sci Rep. 2017 Jul 31;7(1):6932.

15.Zhang Xumei#, Zhao Yaqian, Yan Hai, Liu Huan, Huang Guowei*. Inhibitory effect of homocysteine on rat neural stem cell growth in vitro is associated with reduced protein levels and enzymatic activities of aconitase and respiratory complex III. J Bioenerg Biomembr, 2017 Apr;49(2):131-138.

Grants（最具代表性的，不多于10个）

1.National Natural Science Foundation：Exploring the Mechanism of Homocysteine Induced Cognitive Impairment in Cerebrovascular Disease and the Improving Effect of Folic Acid Based on Nitric Oxide Synthase Mediated Neurovascular Coupling, 82173519,   2022.01-2025.12

2.National Natural Science Foundation: Exploring the Mechanism of Folic Acid's Impact on Cognitive Function after Cerebral Infarction Based on lncRNA and NMDA Receptor Regulation of Synaptic Plasticity, 81874262, 2019.01-2022.12

3.National Natural Science Foundation: Research on the Mechanism of Homocysteine on the Proliferation and Differentiation of Neural Stem Cells through DNA Methylation Pathway, 81373003, 2014.01-2017.12.

4.National Natural Science Foundation: Molecular mechanism research on the regulation of proliferation and differentiation of neural stem cells by folate/homocysteine metabolism related genes, 30901192, 2009.10-2012.12. 

5.BY-HEALTH Nutrition Cooperation Research Fund, A Prospective Cohort Study on the Association between Methyl Metabolism Cycle-Related Nutrients, Three Fatty Acids, and Cognitive Function in the Elderly, 2024.6-2025.12

6.Horizontal project, A Prospective Cohort Study on the Relationship between Homocysteine Metabolism Cycle and GDM based on Precision Nutrition, 2023.12-2025.11,

7.BY-HEALTH Nutrition Cooperation Research Fund, Rapid Screening and Efficacy Study of Probiotics Based on C.elegans Model, 2023.12-2024.12

8.China Postdoctoral Science Foundation, Study on the Effect of Folic Acid and Homocysteine on Neuronal Cells by Autophagy in Rats with Cerebral Infarction (2014M550148), 2014.4-2015.5

9.Tianjin Higher Education Science and Technology Development Fund Project, Effects of Homocysteine on the Proliferation and Differentiation of Neural Stem Cells (20070208), 2007.11-2010.6

10.BY-HEALTH Nutritional Cooperation Research Fund, Exploring the Anti Aging Mechanism of Astaxanthin Based on Autophagy Regulation (TY0181104), 2019.1-2020.12