Wen Li

Associate Professor

Department of Nutrition and Food Hygiene,

School of Public Health Tianjin Medical 

university

22 Qixiangtai Road

Tianjin 300070

Phone: +86-22-83336610

Email Address: liwen828@tmu.edu.cn

Education 

2010.09~2015.07: PhD in Nutrition and Food Hygiene, Tianjin Medical University, Tianjin, China

2005.09~2010.07: Bachelor's in Medicine, Tianjin Medical University, Tianjin, China 

Professional Background 

2018.12~present: Associate Professor, Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China 

2015.07~2018.12: Lecturer, Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China

Awards Received 

1.Distinguished Teacher in Tianjin Universities, 2020

2.3nd level talent, 131 independent innovation, Tianjin, 2015

3.The Best Oral Presentation Award of the 14th Asian Nutrition Conference and the 15th National Nutrition Science Conference of Chinese Nutrition Society in Chengdu, 2023

4.Second Prize of Tianjin Science and Technology Progress Award, 2021, (2/8)

5.Third prize of Basic Skills Competition for Young Teachers of Tianjin Medical University, 2022

Other Roles

1. Membership, Chinese Society of Nutrition

2. Director, Nutrition and Immunology Branch, Chinese Nutrition Society

3. Member, the Nutrition and Health Food Branch of Chinese Nutrition Society

4. Member, Youth Working Committee of Chinese Nutrition Society

5. Secretary, Nutrition and Neuroscience Branch, Chinese Nutrition Society

6. Director, Tianjin Nutrition Society

7. Director, Tianjin Food Society

Publications

1.Zhang L, Chen X, Chen Y, Yan J, Huang G, Li W*. A comparative study evaluating the effectiveness of folate-based B vitamin intervention on cognitive function of older adults under mandatory folic acid fortification policy: A systematic review and meta-analysis of randomized controlled trials. Nutrients. 2024; 16(14):2199. https://doi.org/10.3390/nu16142199. (IF：4.8/5.8，Q1）

2.Sun Y#, Zhou D#, Wang Y, Wang Z, Zhang D, Qian Z, Yan J, Li Z, Huang G, Li W*. Medium-chain triglycerides combined with DHA improve cognitive function by inhibiting neurocyte apoptosis of the brain in SAMP8 mice. Exp Gerontol. 2024 Jul 9:112520. doi: 10.1016/j.exger.2024.112520. (IF：3.3/3.8，Q2）

3.Zhou D#, Sun Y#, Dong C, Wang Z, Zhao J, Li Z, Huang G, Li W*. Folic acid alleviated oxidative stress-induced telomere attrition and inhibited apoptosis of neurocytes in old rats. Eur J Nutr. 2024 Feb;63(1):291-302. doi: 10.1007/s00394-023-03266-x.（IF：4.1/4.6，Q2）

4.Li Z, Cai K, Sun Y, Zhou D, Yan J, Luo S, Huang G, Gao Y, Li W*. Folic acid protects against age-associated apoptosis and telomere attrition of neural stem cells in senescence-accelerated mouse prone 8. Appl Physiol Nutr Metab. 2023 May 1;48(5):393-402. doi: 10.1139/apnm-2022-0111.（IF：2.4/2.8，Q2）

5.Zhou D, Li Z, Sun Y, Yan J, Huang G, Li W*. Early Life Stage Folic Acid Deficiency Delays the Neurobehavioral Development and Cognitive Function of Rat Offspring by Hindering De Novo Telomere Synthesis. Int J Mol Sci. 2022 Jun 22;23(13):6948. doi: 10.3390/ijms23136948.（IF：4.9/5.6，Q1）

6.Huang L, Zhao J, Chen Y, Ma F, Huang G, Li W*. Baseline folic acid status affects the effectiveness of folic acid supplements in cognitively relevant outcomes in older adults: a systematic review. Aging Ment Health. 2022 Mar;26(3):457-463. doi: 10.1080/13607863.2021.1875194.（IF：2.8/3.4，Q2）

7.Wang X, Li Z, Zhu Y, Yan J, Liu H, Huang G, Li W*. Maternal folic acid impacts DNA methylation profile in male rat offspring implicated in neurodevelopment and learning/memory abilities. Genes Nutr. 2021 Jan 11;16(1):1. doi: 10.1186/s12263-020-00681-1.（IF：3.3/3.8，Q2）

8.Duan H, He X, Yang T, Xu N, Wang Z, Li Z, Chen Y, Du Y, Zhang M, Yan J, Sun C, Wang G, Ma F, Li W*, Li X*, Huang G*. Critical Values of Daily Sedentary Time and Its Longitudinal Association with Mild Cognitive Impairment Considering APOE ε4: A Prospective Cohort Study. J Prev Alzheimers Dis. 2024;11(3):582-588. doi: 10.14283/jpad.2024.44. （IF：8.5/6.9，Q1）

9.Zhang D#, Zhou D#, Wang X, Li M, Zhang J, He N, Zhou X, Li Z, Huang G, Li W*, Qian Z*. Selenium and vitamin B2 cosupplementation alleviates high-fat-diet-induced nonalcoholic fatty liver disease in rats by regulating hepatic lipid metabolism. Eur J Lipid Sci Technol. 2024;126(1):2300020. Doi: 10.1002/ejlt.202300020.（IF：1.8/2.5，Q3）

10.Zhou D, Sun Y, Qian Z, Wang Z, Zhang D, Li Z, Zhao J, Dong C, Li W*, Huang G*. Long-term dietary folic acid supplementation attenuated aging-induced hippocampus atrophy and promoted glucose uptake in 25-month-old rats with cognitive decline. J Nutr Biochem. 2023 Jul;117:109328. doi: 10.1016/j.jnutbio.2023.109328. (IF：4.8/5.4，Q1）

11.Fu J#, Zhu Y#, Sun Y, Liu Q, Duan H, Huang L, Zhou D, Wang Z, Zhao J, Li Z, Du Y, Liu H, Ma F, Chen Y, Sun C, Wang G, Li W*, Huang G*. Circulating Amyloid-β and Methionine-Related Metabolites to Predict the Risk of Mild Cognitive Impairment: A Nested Case-Control Study. J Alzheimers Dis. 2022;90(1):389-404. doi: 10.3233/JAD-220373. (IF：3.4/4.2，Q2）

12.Zhou D, Lv X, Wang Y, Liu H, Luo S, Li W*, Huang G*. Folic acid alleviates age-related cognitive decline and inhibits apoptosis of neurocytes in senescence-accelerated mouse prone 8: deoxythymidine triphosphate biosynthesis as a potential mechanism. J Nutr Biochem. 2021 Nov;97:108796. doi: 10.1016/j.jnutbio.2021.1087960955-2863/. (IF：4.8/5.4，Q1）

13.Lv X, Zhou D, Ge B, Chen H, Du Y, Liu S, Ji Y, Sun C, Wang G, Gao Y, Li W*, Huang G*. Association of Folate Metabolites and Mitochondrial Function in Peripheral Blood Cells in Alzheimer's Disease: A Matched Case-Control Study. J Alzheimers Dis. 2019;70(4):1133-1142. doi: 10.3233/JAD-190477. (IF：3.4/4.2，Q2）

Grants

1.National Natural Science Foundation of China: Study on the mechanism of maternal folic acid deficiency on the neurodevelopment of rat offspring based on the proliferation and differentiation of neural stem cells（Grant Number:81602849），2017.01-2019.12

2.Nature Foundation of Tianjin Science and Technology Bureau: Study on the mechanism of synthesis of folic acid from DNA thymidylate on neurodevelopment of offspring rats（Grant Number:19JCQNJC11700），2019.04-2022.03

3.Scientific Research Fund of Chinese Nutrition Society: Study on regional cultural dietary model construction and community application in reducing the risk of hyperlipidemia in the elderly（Grant Number:CNS-YUM2023-14），2024.01-2024.12

4.young elite scientists sponsorship program by CAST (Grant Number:2017QNRC001)，2017.01-2019.12

5.young elite scientists sponsorship program by Tianjin（Grant Number:QT2017021），2017.01-2019.12

6.National Natural Science Foundation of China: The double-edged sword effect of folic acid on the occurrence of colorectal cancer and the synthesis mechanism of DNA thymidylate（Grant Number:82373571），2024.01-2027.12

7.Key Research and Development Plan of the Ministry of Science and Technology: Application demonstration of dietary intervention and evaluation program for impaired Function in the elderly -- Study on dietary intervention program for impaired cognitive and sleep function in the elderly population（Grant Number:2022YFC2010103），2022.07-2025.06

8.National Natural Science Foundation of China: Study on the effect and mechanism of telomere folic acid on nerve cell apoptosis and delay of cognitive decline in the elderly（Grant Number:81730091），2018.01-2022.12

9.National Natural Science Foundation of China: Study on the epigenetic mechanism of folic acid in atherosclerosis（Grant Number:81373002），2014.01-2017.12

10.National Natural Science Foundation of China: Effects of prenatal exposure to phthalate on hypothalamic reproductive nervous system in male rats and its mechanism（Grant Number:81273027），2013.01-2016.12