Xi Chen

Professor

Department of Occupational and Environmental Health

School of Public Health

Tianjin Medical University

22 Qixiangtai Road, Tianjin 300070

Phone: +86-22-83336633

Email Address:  chenxi@tmu.edu.cn

Research direction

Environmental Health 

1. Health effects of environmental endocrine disruptors (EDCs) and persistent organic pollutants (POPs)

2. Health effects of air pollution

Education

Ph.D.  Tianjin Medical University, Tianjin, China, 2012 

MD     Tianjin Medical University, Tianjin, China, 2009

Bachelor     Tianjin Medical University, Tianjin, China, 2006

Professional Experience

01/2021–   Professor, Tianjin Medical University, China

12/2023–06/2024  Visiting scholar, University of Birmingham, UK

01/2015–12/2020  Associate Professor, Tianjin Medical University, China

06/2015–07/2016  Visiting scholar, UC Berkeley, US

09/2012–12/2014  Instructor, Tianjin Medical University, China

Project

1.Study on the Role of Membrane Receptor Pathway Regulation of Lipid Microenvironment in the Effect of Tetrabromobisphenol A/S on Breast Cancer Development. Key Project of Tianjin Municipal Education Commission. 2023.01-2025.12. Principal Investigator

2.Study on the Impact of Tetrabromobisphenol A and Its Derivatives on Breast Cancer Development and the Mediating Role of Adipose Tissue Microenvironment. Key Project of Tianjin Natural Science Foundation. 2023.10-2026.09. Principal Investigator

3.Study on the effect of perfluorinated compounds exposure on breast cancer and its estrogen receptor mediated mechanism. National Natural Science Foundation of China. 2020.01-2023.12. Principal Investigator

Publication

1.Hongyue Sun#, Xi Chen#, Wenzhong Huang#, Jing Wei#, Xueli Yang, Anqi Shan, Liwen Zhang, Honglu Zhang, Jiayu He, Chengjie Pan, Jingjing Li, Jing Wu, Tong Wang, Jie Chen, Yuming Guo, Shilu Tong, Guanghui Dong*, Nai-Jun Tang*. Association between Long-Term Exposure to PM2.5 Inorganic Chemical Compositions and Cardiopulmonary Mortality: A 22-Year Cohort Study in Northern China. Environ. Health 2024, 2, 8, 530–540.

2.Qianfeng Liu, Dan Wang, Wen Li, Xiaoyu Li, Ze Yang, Ai Zhang, Jiayu He, Xu Chen, Ying Chang, Xi Chen*, Nai-Jun Tang. Association of chromosomal abnormalities with prenatal exposure to heavy metals: A nested case-control study in high-risk pregnant women in China. Ecotoxicol Environ Saf. 2023 Oct 15:265:115518.

3.Huang W#, Zhou Y#, Chen X#, Zeng X#, Knibbs LD, Zhang Y, Jalaludin B, Dharmage SC, Morawska L, Guo Y, Yang X, Zhang L, Shan A, Chen J, Wang T, Heinrich J, Gao M, Lin L, Xiao X, Zhou P, Yu Y, Tang N*, Dong G*. Individual and joint associations of long-term exposure to air pollutants and cardiopulmonary mortality: a 22-year cohort study in Northern China. Lancet Reg Health West Pac. 2023 May 4;36:100776.

4.Li X, Song F, Liu X, Shan A, Huang Y, Yang Z, Li H, Yang Q, Yu Y, Zheng H, Cao XC, Chen D, Chen KX, Chen X*, Tang NJ*. Perfluoroalkyl substances (PFASs) as risk factors for breast cancer: a case-control study in Chinese population. Environ Health. 2022 Sep 9;21(1):83.

5.Zhang A, Wang R, Liu Q, Yang Z, Lin X, Pang J, Li X, Wang D, He J, Li J, Zhang M, Yu Y, Cao XC, Chen X, Tang NJ. Breast adipose metabolites mediates the association of tetrabromobisphenol a with breast cancer: A case-control study in Chinese population. Environ Pollut. 2023 Jan 1;316(Pt 1):120701.

6.Li X, Sun X, Zhang A, Pang J, Li Y, Yan M, Xu Z, Yu Y, Yang Z, Chen X, Wang X, Cao XC, Tang NJ. Breast microbiome associations with breast tumor characteristics and neoadjuvant chemotherapy: A case-control study. Front Oncol. 2022 Sep 12;12:926920.

7.Anqi Shan#, Xi Chen#, Xueli Yang, Baoqun Yao, Fengchao Liang, Ze Yang, Fangchao Liu, Song Chen, Xiaochang Yan, Jianfeng Huang, Shaoye Bo, Nai-Jun Tang, Dongfeng Gu, Hua Yan*. Association between long-term exposure to fine particulate matter and diabetic retinopathy among diabetic patients: A national cross-sectional study in China. Environ Int. 2021 Apr 17;154:106568.

8.Wang L, Guo P, Tong H, Wang A, Chang Y, Guo X, Gong J, Song C, Wu L, Wang T, Hopke PK, Chen X*, Tang NJ*, Mao H*. Traffic-related metrics and adverse birth outcomes: A systematic review and meta-analysis. Environ Res. 2020 Sep;188:109752.

9.Anqi Shan, Ling Leng, Jing Li, Xiu-mei Luo, Ya-jiao Fan, Qiaoyun Yang, Qun-hui Xie, Yang-sheng Chen, Chun-sheng Ni, Li-ming Guo, Hua Tang, Xi Chen*, Nai-jun Tang*. TCDD-induced antagonism of MEHP-mediated migration and invasion partly involves aryl hydrocarbon receptor in MCF7 breast cancer cells. Journal of Hazardous Materials. Volume 398, 5 November 2020, 122869. doi.org/10.1016/j.jhazmat.2020.122869

10.Shan A, Zhang Y, Zhang LW, Chen X, Li X, Wu H, Yan M, Li Y, Xian P, Ma Z, Li C, Guo P, Dong GH, Liu YM, Chen J, Wang T, Zhao BX, Tang NJ*. Associations between the incidence and mortality rates of type 2 diabetes mellitus and long-term exposure to ambient air pollution: A 12-year cohort study in northern China. Environ Res. 2020 Jul;186:109551.

11.Yan M, Li C, Zhang L, Chen X, Yang X, Shan A, Li X, Wu H, Ma Z, Zhang Y, Guo P, Dong G, Liu Y, Chen J, Wang T, Zhao B, Tang NJ*. Association between long-term exposure to Sulfur dioxide pollution and hypertension incidence in northern China: a 12-year cohort study. Environ Sci Pollut Res Int. 2020 Jun; 27(17): 21826-21835.

12.Shan A#, Zhang Y, Zhang LW, Chen X, Li X, Wu H, Yan M, Li Y, Xian P, Ma Z, Li C, Guo P, Dong GH, Liu YM, Chen J, Wang T, Zhao BX, Tang NJ*. Associations between the incidence and mortality rates of type 2 diabetes mellitus and long-term exposure to ambient air pollution: A 12-year cohort study in northern China. Environ Res, 2020 Jul; 186: 109551.

13.Wang L#, Guo P, Tong H, Wang A, Chang Y, Guo X, Gong J, Song C, Wu L, Wang T, Hopke PK, Chen X*, Tang NJ*, Mao H*. Traffic-related metrics and adverse birth outcomes: A systematic review and meta-analysis. Environ Res, 2020 May 30; 188: 109752.

14.Shan A, Li M, Li X, Li Y, Yan M, Xian P, Chang Y, Chen X*, Tang NJ. BDE-47 decreases progesterone levels in BeWo cells by interfering with mitochondrial functions and genes related to cholesterol transport. Chem Res Toxicol. 2019 Feb 4. doi: 10.1021/acs.chemrestox.8b00312. [Epub ahead of print]

15.Zhang HJ, Liu YN, Xian P, Ma J, Sun YW, Chen JS, Chen X*, Tang NJ*. Maternal exposure to TCDD during gestation advanced sensory-motor development, but induced impairments of spatial learning and memory in adult male rat offspring. Chemosphere. 2018 Aug 23;212:678-686.  

Membership of Academic Society

Branch of Industrial Toxicology, Chinese Society of Toxicology (CSOT)

Branch of Environmental Health, Chinese Preventive Medicine Association (CPMA) 

Branch of Toxicology, Chinese Preventive Medicine Association (CPMA)

Branch of Biomarkers, Chinese Society of Environmental Mutagens