Full Name  Zhongze Fang

Professor

Department of Health Toxicology and Health Inspection and Quarantine, School of Public Health, Tianjin Medical University

22 Qixiangtai Road, Tianjin 300070

Phone: +86-22-83336122

Email Address: fangzhongze@tmu.edu.cn

Education 

Ph.D., Biochemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 2006-2011

B.S., Engineering, Dalian University of Technology, 2002-2006

Professional Background 

2014-Present, Professor, Tianjin Medical University, Department of Health Toxicology and Health Inspection and Quarantine, School of Public Health 

2011-2014, Postdoctoral fellow, Center for Cancer Research, National Institute of Health (NIH), United States

Awards Received 

1. Liaoning Provincial Natural Science Academic Achievement Award, 2011, Rank (1/1)

2. First Prize of Natural Science Academic Achievements of Jinzhou City, 2013, Rank (1/4)

3. Tianjin “131” Innovative Talents, 2014

4. Excellence Talent PI of Tianjin Medical University (2017-2019)

5. “Training Program for Young and Middle-aged Backbone Innovative Talents” of Tianjin Universities (2017-2020)

6. 2018 Tianjin Innovation Promotion Program for Leading Talents

7. First Prize of Scientific and Technological Achievements of Tianjin Medical University in 2020

Other Roles

1. Deputy Secretary General, Chinese Society of Biophysics, Intestinal Flora Branch

2. Director, Chinese Society of Environmental Mutagens

3. Member of Immunotoxicology Committee, Chinese Society of Toxicology

4. Member, Youth Committee, Chinese Society of Toxicology

5. Member, Education Committee, Chinese Society of Toxicology

6. Member, Specialized Committee on Biochemical and Molecular Toxicology, Chinese Society of Toxicology

7. Vice Chairman, Youth Committee, Drug Metabolism Specialized Committee, Chinese Society of Pharmacology

8. Member, Specialized Committee on Therapeutic Pharmacology Monitoring, Chinese Society of Pharmacology

9. Member, Risk Assessment Committee, Chinese Society of Environmental Mutagens (CSEM)

10. Member, Biomarker Committee, Chinese Society of Environmental Mutagens (CSEM)

11. Vice Chairman, Environment and Health Youth Committee, Beijing Society of Environmental Mutagens (BSEM)

12. Member, Metabolic Cardiovascular Disease Group, Cardiovascular Disease Section, Chinese Medical Association (CSC)

13. Chairman, Toxicology Branch, Tianjin Society of Preventive Medicine, China

14. Standing member of the Therapeutic Pharmacology Monitoring Committee of Tianjin Pharmacology Society

15. Standing member of Epidemiology Committee of Tianjin Heart Association

Publications 

1. Liu YZ, Zhang ZP, Fu ZW, Yang K, Ding N, Hu LG, Fang ZZ, Zhuo X. Per- and polyfluoroalkyl substances display structure-dependent inhibition towards UDP-glucuronosyltransferases. Environ Pollut. 2019 Nov;254(Pt B): 113093.

2. Wang F, Wang S, Yang K, Liu YZ, Yang K, Chen Y, Fang ZZ. Inhibition of UDP-glucuronosyltransferases (UGTs) by bromophenols (BPs). Chemosphere. 2020 Jan;238: 124645.

3. Sun HZ, Qin GQ, Wang FG, Bai Y, Zhang Z, Fang ZZ. Hydroxylated polychlorinated biphenyls (OH-PCBs) exert strong inhibitory effects towards human carboxylesterases (CESs). Sci Total Environ. 2020 Nov 25;745: 141140.

4. Liu NR, Yang K, Li WT, Pang ZH, Zhang Q, Wang JJ, Dang WX, Jia RY, Fu ZW, Li YX, Yao ZH, Fang ZZ. Evaluation of the inhibition of chlorophenols towards human cytochrome P450 3A4 and differences among various species. Sci Total Environ. 2020 Jul 1;724: 138187.

5. Yang Q, Bai Y, Qin GQ, Jia RY, Zhu W, Zhang D, Fang ZZ. Inhibition of UDP-glucuronosyltransferases (UGTs) by polycyclic aromatic hydrocarbons (PAHs) and hydroxy-PAHs (OH-PAHs). Environ Pollut. 2020 Aug;263(Pt B): 114521.

6. Liu J, Li J, Li S, Leng J, Li W, Yang W, Huo X, Chen L, Ma RCW, Hu G, Fang Z, Yang X. Circulating Lysophosphatidylcholines in Early Pregnancy and Risk of Gestational Diabetes in Chinese Women. J Clin Endocrinol Metab. 2020 Apr 1;105(4):dgaa058.

7. Jia RY, Zhang ZP, Qin GQ, Zhang W, Yang K, Liu YZ, Jiang C, Fang ZZ. Inhibition of hydroxylated polychlorinated biphenyls (OH-PCBs) on sulfotransferases (SULTs). Environ Pollut. 2021 Dec 15;291: 118214.

8. Zhang Z, Du Z, Liu Q, Wu T, Tang Q, Zhang J, Huang C, Huang Y, Li R, Li Y, Zhao Y, Zhang G, Zhou J, Huang H, Fang Z, He J. Glucagon-like peptide 1 analogue prevents cholesterol gallstone formation by modulating intestinal farnesoid X receptor activity. Metabolism. 2021 May;118: 154728.

9. Wang Y, Zhang J, Jia X, Chen M, Wang H, Ji G, Zhou H, Fang Z, Gao Z. TENG-based self-powered device- the heart of life. Nano Energy. 2024 Jan; 119: 109080

10. Ji G, Wang J, Wang Z, Zhang S, Fang Z, Wang Y, Gao Z. Transient paper-based electrochemical biosensor Fabricated by superadditive Cu-TCPP(Fe)/Mxene for Multipathway non-invasive, highly sensitive detection of Bodily metabolites. Biosens Bioelectron. 2024 Oct 1;261: 116509.

Grants

1. National Natural Science Foundation of China: The mechanism of hydroxyphenanthrene (OH-Phe)-induced gestational diabetes mellitus (GDM) through the bile acids-farnesoid X receptor axis (Grant: Number: 82473677). 2025.01-2028.12

2. National Natural Science Foundation of China: Mechanistic study of gestational diabetes mellitus caused by polycyclic aromatic hydrocarbons induced ceramide metabolism disorders (Grant Number: 82273676). 2023.01-2026.12

3. National Natural Science Foundation of China: Study on the regulatory role of intestinal flora on metabolic diseases and intervention strategies (Grant Number: 92357305). 2024.01-2026.12

4. National Key Programs of the Ministry of Science and Technology: Molecular mechanisms of gut microbiome-drug interactions influencing efficacy and safety (Grant Number: 2021YFA1301200). 2021.12-2026.11

5. National Key Programs of the Ministry of Science and Technology: Characterization of intestinal flora at different developmental stages and its effect on development (Grant Number: 2019YFA0802300). 2019.12-2024.11

6. National Key Programs of the Ministry of Science and Technology: Early identification techniques for the health effects of atmospheric pollution on the respiratory and cardiovascular systems (Grant Number: 2017YFC0211600). 2017.07-2021.07

7. National Key Programs of the Ministry of Science and Technology: Molecular typing of first stroke in H-type hypertension based on histologic feature profiling (Grant Number: 2016YFC0903102). 2016.07-2018.12

8. Tianjin Municipal Education Commission, Tianjin Distinguished Professor Fund. 2019.09-2023.09