Zhenshu Li

Lecturer

Department of Nutrition and Food

Hygiene, School of Public Health

Tianjin Medical University

22 Qixiangtai Road

Tianjin 300070

Phone: +86-22-83336610

Email Address: lizhenshu@tmu.edu.cn

Education

Ph.D., Nutrition and Food Hygiene, Tianjin Medical University, Tianjin, China, 2022

B.S., Preventive Medicine, Tianjin Medical University, Tianjin, China, 2016

Professional Background

2022- Lecturer, Tianjin Medical University, Department of Nutrition and Food Hygiene, School of Public Health 

Other Roles

Member, Chinese Nutrition Society, Nutritional Toxicology Branch

Publications

1.Zhenshu Li#, Wen Li#, Dezheng Zhou, Jing Zhao, Yue Ma, Ling Huang, Cuixia Dong, John X. Wilson, Guowei Huang*. Alleviating Oxidative Damage-Induced Telomere Attrition: A Potential Mechanism for Inhibition by Folic Acid of Apoptosis in Neural Stem Cells. Molecular Neurobiology, 2022, 59(1): 590-602.

2.Zhenshu Li#, Dezheng Zhou#, Dalong Zhang#, Jing Zhao, Wen Li, Yue Sun, Yongjie Chen, Huan Liu, John X Wilson, Zhiyong Qian*, Guowei Huang*. Folic Acid Inhibits Aging-Induced Telomere Attrition and Apoptosis in Astrocytes In Vivo and In Vitro. Cerebral Cortex, 2022, 32(2): 286-297.

3.Zhenshu Li, Ke Cai, Yue Sun, Dezheng Zhou, Jing Yan, Suhui Luo, Guowei Huang, Yuxia Gao, Wen Li*. Folic acid protects against age-associated apoptosis and telomere attrition of neural stem cells in senescence-accelerated mouse prone 8. Applied Physiology, Nutrition, and Metabolism, 2023, 48(5): 393-402.

4.Qinghan Ren#, Jing Zhao#, Yunfei Ma, Tongtong Li, Xin He, Jing Yan, Guowei Huang, Wen Li*, Zhenshu Li*. Folic acid supplementation inhibits autophagy-dependent apoptosis in rat brain neural cells and HT-22 neurons via the p53/mTOR signaling pathway. The Journal of Nutritional Biochemistry, 2025 Nov: 145: 110014. doi: 10.1016/j.jnutbio.2025.110014.

5.Dalong Zhang#, Zehao Wang#, Shuangshuang Guo, Yue Sun, Dezheng Zhou, Wen Li, Jing Yan, Yongjie Chen, Suhui Luo, Guowei Huang, Zhiyong Qian, Zhenshu Li*. 18F-Fluorodeoxyglucose positron emission tomography/computed tomography imaging reveals the protective effect of docosahexaenoic acid on glucose metabolism by reducing brain 27-hydroxycholesterol. Experimental Gerontology, 2024, 196: 112577.

6.Cheng Cheng#, Zehao Wang#, Huilian Duan, Qi Wu, Xukun Chen, Liyang Zhang, Di Wang, Mengtong Yang, Zhenghua Huang, Zhaolun Su, Zhongxia Li, Ruikun He, Wen Li, Zhenshu Li*, Guowei Huang*. Methods established for the detection of mineral levels in whole blood by the dried blood spot technique. Talanta, 2025, 282: 126963.

7.Guoquan Zhang#, Qinghan Ren#, Ying Lin, Dezheng Zhou, Li Huang, Wen Li, Hong Chang, Guowei Huang, Zhenshu Li*, Jing Yan*. Parental Folic Acid Deficiency Delays Neurobehavioral Development in Rat Offspring by Inhibiting The Differentiation of Neural Stem Cells into Neurons. The Journal of Nutritional Biochemistry, 2023, 122: 109455.

8.Qinghan Ren#, Guoquan Zhang#, Ruiting Yan, Dezheng Zhou, Li Huang, Qianwen Zhang, Wen Li, Guowei Huang, Zhenshu Li*, Jing Yan*. SAM/SAH Mediates Parental Folate Deficiency-Induced Neural Cell Apoptosis in Neonatal Rat Offspring: The Expression of Bcl-2, Bax, and Caspase-3. International Journal of Molecular Sciences, 2023, 24(19): 14508.

9.Zehao Wang#, Dalong Zhang#, Cheng Cheng, Zhenzhen Lin, Dezheng Zhou, Yue Sun, Wen Li, Jing Yan, Suhui Luo, Zhiyong Qian, Zhenshu Li*, Guowei Huang*. Supplementation of Medium-Chain Triglycerides Combined with Docosahexaenoic Acid Inhibits Amyloid Beta Protein Deposition by Improving Brain Glucose Metabolism in APP/PS1 Mice. Nutrients, 2023, 15(19): 4244.

10.Qian Liu#, Zhenshu Li#, Ling Huang#, Dezheng Zhou, Jingzhu Fu, Huilian Duan, Zehao Wang, Tong Yang, Jing Zhao, Wen Li, Huan Liu, Fei Ma, Changqing Sun, Guangshun Wang, Yue Du, Meilin Zhang, Yongjie Chen*, Guowei Huang*. Telomere and mitochondria mediated the association between dietary inflammatory index and mild cognitive impairment: A prospective cohort study. Immunity & Ageing, 2023, 20(1): 1.

11.Dezheng Zhou#, Zhenshu Li#, Yue Sun, Jing Yan, Guowei Huang, Wen Li*. Early Life Stage Folic Acid Deficiency Delays the Neurobehavioral Development and Cognitive Function of Rat Offspring by Hindering De Novo Telomere Synthesis. International Journal of Molecular Sciences, 2022, 23(13): 6948.

Grants

1.General Project of Scientific Research Program of Tianjin Municipal Education Commission: Study on the effect of maternal folate deficiency on neuronal damage in rat offspring based on microglial inflammation response (Grant Number: 2022KJ203), 2022.01- 2025.12. 

2.National Natural Science Foundation of China: The double-edged sword effect of folic acid on the occurrence of colorectal cancer and the mechanism of DNA thymidine synthesis (Grant Number: 82373571), 2024.01- 2027.12.

3.National Natural Science Foundation of China: Research on the effect of folate on neuronal apoptosis and delaying cognitive decline in the elderly and the mechanism of telomere (Grant Number: 81730091), 2018.01- 2022.12. 

4.National Natural Science Foundation of China: Study on the effect of of medium chain triglycerides combined with DHA on improving cognitive impairment in mild cognitive impairment and the mechanism of brain energy metabolism (Grant Number: 82073547), 2021.01- 2024.12.