Zhenshu Li

Lecturer

Department of Nutrition and Food

Hygiene, School of Public Health

Tianjin Medical University

22 Qixiangtai Road

Tianjin 300070

Phone: +86-22-83336610

Email Address: lizhenshu@tmu.edu.cn

Education

Ph.D., Nutrition and Food Hygiene, Tianjin Medical University, Tianjin, China, 2022

B.S., Preventive Medicine, Tianjin Medical University, Tianjin, China, 2016

Professional Background

2022- Lecturer, Tianjin Medical University, Department of Nutrition and Food Hygiene, School of Public Health 

Other Roles

Member, Chinese Nutrition Society, Nutritional Toxicology Branch

Publications

1.Zhenshu Li#, Wen Li#, Dezheng Zhou, Jing Zhao, Yue Ma, Ling Huang, Cuixia Dong, John X. Wilson, Guowei Huang*. Alleviating Oxidative Damage-Induced Telomere Attrition: A Potential Mechanism for Inhibition by Folic Acid of Apoptosis in Neural Stem Cells. Molecular Neurobiology, 2022, 59(1): 590-602.

2.Zhenshu Li#, Dezheng Zhou#, Dalong Zhang#, Jing Zhao, Wen Li, Yue Sun, Yongjie Chen, Huan Liu, John X Wilson, Zhiyong Qian*, Guowei Huang*. Folic Acid Inhibits Aging-Induced Telomere Attrition and Apoptosis in Astrocytes In Vivo and In Vitro. Cerebral Cortex, 2022, 32(2): 286-297.

3.Zhenshu Li, Ke Cai, Yue Sun, Dezheng Zhou, Jing Yan, Suhui Luo, Guowei Huang, Yuxia Gao, Wen Li*. Folic acid protects against age-associated apoptosis and telomere attrition of neural stem cells in senescence-accelerated mouse prone 8. Applied Physiology, Nutrition, and Metabolism, 2023, 48(5): 393-402.2023.

4.Guoquan Zhang#, Qinghan Ren#, Ying Lin, Dezheng Zhou, Li Huang, Wen Li, Hong Chang, Guowei Huang, Zhenshu Li*, Jing Yan*. Parental Folic Acid Deficiency Delays Neurobehavioral Development in Rat Offspring by Inhibiting The Differentiation of Neural Stem Cells into Neurons. The Journal of Nutritional Biochemistry, 2023, 122: 109455.

5.Qinghan Ren#, Guoquan Zhang#, Ruiting Yan, Dezheng Zhou, Li Huang, Qianwen Zhang, Wen Li, Guowei Huang, Zhenshu Li*, Jing Yan*. SAM/SAH Mediates Parental Folate Deficiency-Induced Neural Cell Apoptosis in Neonatal Rat Offspring: The Expression of Bcl-2, Bax, and Caspase-3. Interntional Journal of Molecular Sciences, 2023, 24(19): 14508.

6.Zehao Wang#, Dalong Zhang#, Cheng Cheng, Zhenzhen Lin, Dezheng Zhou, Yue Sun, Wen Li, Jing Yan, Suhui Luo, Zhiyong Qian, Zhenshu Li*, Guowei Huang*. Supplementation of Medium-Chain Triglycerides Combined with Docosahexaenoic Acid Inhibits Amyloid Beta Protein Deposition by Improving Brain Glucose Metabolism in APP/PS1 Mice. Nutrients, 2023, 15(19): 4244.

7.Qian Liu#, Zhenshu Li#, Ling Huang#, Dezheng Zhou, Jingzhu Fu, Huilian Duan, Zehao Wang, Tong Yang, Jing Zhao, Wen Li, Huan Liu, Fei Ma, Changqing Sun, Guangshun Wang, Yue Du, Meilin Zhang, Yongjie Chen*, Guowei Huang*. Telomere and mitochondria mediated the association between dietary inflammatory index and mild cognitive impairment: A prospective cohort study. Immunity & Ageing, 2023, 20(1): 1.

8.Dezheng Zhou#, Zhenshu Li#, Yue Sun, Jing Yan, Guowei Huang, Wen Li*. Early Life Stage Folic Acid Deficiency Delays the Neurobehavioral Development and Cognitive Function of Rat Offspring by Hindering De Novo Telomere Synthesis. International Journal of Molecular Sciences, 2022, 23(13): 6948.

9.Wen Li#, Zhenshu Li#, Dezheng Zhou, Xumei Zhang, Jing Yan, Guowei Huang*. Maternal Folic Acid Deficiency Stimulates Neural Cell Apoptosis via MiR-34a Associated with Bcl-2 in The Rat Foetal Brain. International Journal of Developmental Neuroscience, 2019, 72: 6-12.

Grants

1.General Project of Scientific Research Program of Tianjin Municipal Education Commission: Study on the effect of maternal folate deficiency on neuronal damage in rat offspring based on microglial inflammation response (Grant Number: 2022KJ203), 2022.01- 2025.12. 

2.National Natural Science Foundation of China: Research on the effect of folate on neuronal apoptosis and delaying cognitive decline in the elderly and the mechanism of telomere (Grant Number: 81730091), 2018.01- 2022.12.  

3.National Natural Science Foundation of China: Study on the effect of folate on brain development and epigenetic mechanism through DNA methylation pathway (Grant Number: 81472967), 2015.01- 2018.12.

4.National Natural Science Foundation of China: Study on the effect of of medium chain triglycerides combined with DHA on improving cognitive impairment in mild cognitive impairment and the mechanism of brain energy metabolism (Grant Number: 82073547), 2021.01- 2024.12.

5.National Natural Science Foundation of China: The double-edged sword effect of folic acid on the occurrence of colorectal cancer and the mechanism of DNA thymidine synthesis (Grant Number: 82373571), 2024.01- 2027.12.