黄国伟 教授
营养与食品卫生学系
电子邮件 huangguowei@tmu.edu.cn
简历
研究方向
营养与疾病，营养与神经科学。
学习经历
1.1981～1986，天津医科大学，预防医学，学士学位
2.1986～1989，天津医科大学，营养与食品卫生学，硕士学位
3.2005～2009，天津科技大学，食品科学，博士学位
工作经历
1.2018.04至今 天津医科大学营养与食品卫生学系教授，系主任
2.2005～2018 天津医科大学营养与食品卫生学教研室系教授，系主任，院长
3.2003～2004 加拿大西安大略大学医学院访问学者
4.2000～2005 天津医科大学公共卫生学院营养研究室教授，副院长
5.1995～2000 天津医科大学公共卫生学院营养研究室副教授
6.1989～1995 天津医科大学公共卫生学院营养与食品卫生学教研室助教、讲师
近五年主要承担的课题
1. 国家自然科学基金重点项目“基于端粒叶酸对神经细胞凋亡及延缓老年人认知减退的作用及机制研究”，项目编号：81730091，2018.1-2022.12，资助经费：300万元，主持。
2. 国家自然科学基金面上项目“中链甘油三酯联合DHA改善轻度认知障碍认知减退的脑能量代谢机制研究”，项目编号：82073547，2021.1-2024.12，资助经费：57万元，主持。
3. 国家自然科学基金面上项目“叶酸通过DNA甲基化途径对脑发育表观遗传学作用机制的研究”，项目编号：81472967，2015.1-2018.12，资助经费：90万元，主持。
4. 天津市科技支撑重点项目“以社区为基础叶酸、维生素B12联合防治阿尔茨海默病干预技术研究”，项目编号：15ZCZDSY01040，2015.10-2018.9，资助经费：30万元，主持。
5. 汤臣倍健股份有限公司科研合作项目“汤臣倍健（R）磷脂酰丝氨酸银杏叶软胶囊对轻度认知障碍老年人干预效果研究” ，项目编号：C01202108020003，2021.09-2024.06，资助经费：150万元，主持。
6. 汤臣倍健营养科学研究基金项目“叶酸和DHA联合应用对轻度认知功能障碍老年人干预作用的研究”，项目编号：TY0151102，2016.1-2019.6，资助经费：35万元，主持。
近五年作为通讯作者发表的主要文章（*为通讯作者）
1. Mengyue Li#, Wen Li#, Yiming Gao, Yongjie Chen, Dong Bai, Jinxi Weng, Yue Du, Fei Ma, Xinyan Wang, Huan Liu*, Guowei Huang*. Effect of folic acid combined with docosahexaenoic acid intervention on mild cognitive impairment in elderly: a randomized double-blind, placebo-controlled trial. Eur J Nutr. 2021, 60(4): 1795-1808.
2. Huilian Duan#, Yue Sun, Jingzhu Fu, Qian Liu, Ling Huang, Zehao Wang, Jing Zhao, Zhenshu Li, Wen Li, Huan Liu, Fei Ma, Yongjie Chen, Changqing Sun, Guangshun Wang, Yue Du*, Guowei Huang*. APOEε4-stratified longitudinal association between daytime nap, sleep apnea and mild cognitive impairment: a prospective cohort study. Eur J Neurol. 2022 Feb 1. doi: 10.1111/ene.15269. Online ahead of print.
3. Dezheng Zhou#, Xin Lv, Yalan Wang, Huan Liu, Suhui Luo, Wen Li*, Guowei Huang*. Folic acid alleviates age-related cognitive decline and inhibits apoptosis of neurocytes in senescence-accelerated mouse prone 8: deoxythymidine triphosphate biosynthesis as a potential mechanism. J Nutr Biochem. 2021, 97: 108796.
4. Zhenshu Li#, Wen Li#, Dezheng Zhou, Jing Zhao,Yue Ma, Ling Huang, Cuixia Dong, John X. Wilson, Guowei Huang*. Alleviating oxidative damage-induced telomere attrition: a potential mechanism for inhibition by folic acid of apoptosis in neural stem cells. Mol Neurobiol. 2022, 59(1): 590-602.
5. Zhenshu Li#, Dezheng Zhou#, Dalong Zhang#, Jing Zhao, Wen Li, Yue Sun,Yongjie Chen, Huan Liu, John X Wilson, Zhiyong Qian*, Guowei Huang*. Folic Acid Inhibits Aging-Induced Telomere Attrition and Apoptosis in Astrocytes In Vivo and In Vitro. Cereb Cortex. 2022, 32(2): 286-297.
6. Qian Liu#, Dongtao Zhou, Huilian Duan, Yun Zhu, Yue Du, Changqing Sun, Hongyan Lin, Mengdi Jin, Jingzhu Fu, Yuxia Gao, Fei Ma, Yongjie Chen, Meilin Zhang*, Guowei Huang*. Association of dietary inflammatory index and leukocyte telomere length with mild cognitive impairment in Chinese older adults. Nutr Neurosci. 2021 Dec 26; 1-10. doi: 10.1080/1028415X.2021.2017660. Online ahead of print.
7. Huilian Duan#, Changqing Sun#, Yun Zhu#, Qian Liu, Yue Du, Hongyan Lin, Mengdi Jin, Jingzhu Fu, Fei Ma, Wen Li, Huan Liu, Jing Yan, Yongjie Chen, Guangshun Wang, Guowei Huang*. Association of Dietary Habits with Mild Cognitive Impairment among Elderly in Rural Area of North China. Curr Alzheimer Res. 2021, 18(3): 256-264.
8. Yongjie Chen#, Yue Du#, Zhuoyu Sun#, Qian Liu, Changqing Sun, Hongyan Lin, Mengdi Jin, Jingzhu Fu, Fei Ma, Wen Li, Huan Liu, Xumei Zhang, Guangshun Wang*, Guowei Huang*. Interactions Between Handgrip Strength and Serum Folate and Homocysteine Levels on Cognitive Function in the Elderly Chinese Population. J Alzheimers Dis. 2021, 80(4): 1503-1513.
9. Jingzhu Fu#, Qian Liu#, Meilin Zhang#, Changqing Sun, Yue Du, Yun Zhu, Hongyan Lin, Mengdi Jin, Fei Ma, Wen Li, Huan Liu, Jing Yan, Yongjie Chen, Guangshun Wang, Guowei Huang*. Association between methionine cycle metabolite-related diets and mild cognitive impairment in older Chinese adults: a population-based observational study. Nutr Neurosci. 2021 Jan 25; 1-14. doi: 10.1080/1028415X.2021.1872959. Online ahead of print.
10. Jingzhu Fu#, Qian Liu#, Yue Du#, Yun Zhu#, Changqing Sun, Hongyan Lin, Mengdi Jin, Fei Ma, Wen Li, Huan Liu, Xumei Zhang, Yongjie Chen, Zhuoyu Sun, Guangshun Wang*, Guowei Huang*. Age- and Sex-Specific Prevalence and Modifiable Risk Factors of Mild Cognitive Impairment among Older Adults in China: A Population-Based Observational Study. Front Aging Neurosci. 2020, 12: 578742.
11. Lujia Cao#, Yuyan Liu#, Xuan Liang, Yuzhi Zheng, Wen Li, Jing Yan*, Guowei Huang*. Association between dietary patterns during the third trimester and the risk of postpartum depression in China. J Affect Disord. 2020, 264: 370-375.
12. Xin Lv#, Xinyan Wang#, Yalan Wang, Dezheng Zhou, Wen Li, John X. Wilson, Hong Chang, Guowei Huang*. Folic acid delays age-related cognitive decline in senescence-accelerated mouse prone 8: alleviating telomere attrition as a potential mechanism. Aging (Albany NY). 2019, 11(22): 10356-10373.
13. Wen Li#, Yue Ma#, Zhenshu Li, Xin Lv, Xinyan Wang, Dezheng Zhou, Suhui Luo, John X. Wilson, Guowei Huang*. Folic Acid Decreases Astrocyte Apoptosis by Preventing Oxidative Stress-Induced Telomere Attrition. Int J Mol Sci. 2019, 21(1): 62.
14. Fei Ma#, Xuan Zhou#, Qing Li, Jiangang Zhao, Aili Song, Peilin An, Yue Du, Weili Xu, Guowei Huang*. Effects of Folic Acid and Vitamin B12, Alone and in Combination of Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design. Curr Alzheimer Res. 2019, 16(7): 622-632.
15. Xin Lv#, Dongtao Zhou, Baojin Ge, Hui Chen, Yue Du, Shuai Liu , Yong Ji, Changqing Sun，Guangshun Wang, Wen Li*, Guowei Huang*. Association of Folate Metabolites and Mitochondrial Function in Peripheral Blood Cells in Alzheimer’s Disease: A Matched Case-Control Study. J Alzheimers Dis. 2019, 70(4): 1133-1142.
16. Jing Yan#, Yun Zhu#, Lujia Cao#, Yuyan Liu,Yuzhi Zheng, Wen Li, Guowei Huang*. Effects of maternal folic acid supplementation during pregnancy on infant neurodevelopment at 1 month of age: a birth cohort study in China. Eur J Nutr. 2020, 59(4): 1345-1356.
17. Fei Ma#, Qing Li, Xuan Zhou, Jiangang Zhao, Aili Song, Wen Li, Huan Liu, Weili Xu, Guowei Huang*. Effects of folic acid supplementation on cognitive function and Aβ-related biomarkers in mild cognitive impairment: a randomized controlled trial. Eur J Nutr. 2019, 58(1): 345-356.
18. Xinyan Wang#, Wen Li, Zhenshu Li, Yue Ma, Jing Yan, John X. Wilson, Guowei Huang*. Maternal Folic Acid Supplementation During Pregnancy Promotes Neurogenesis and Synaptogenesis in Neonatal Rat Offspring. Cereb Cortex. 2019, 29(8): 3390-3397.
19. Shanshan Cui#, Xin Lv#, Wen Li, Zhenshu Li, Huan Liu, Yuxia Gao*, Guowei Huang*. Folic acid modulates VPO1 DNA methylation levels and alleviates oxidative stress-induced apoptosis in vivo and in vitro. Redox Biol. 2018, 19: 81-91.
20. Wen Li#, Zhenshu Li, Shou Li, Xinyan Wang, John X. Wilson, Guowei Huang*. Periconceptional Folic Acid Supplementation Benefit to Development of Early Sensory-Motor Function through Increase DNA Methylation in Rat Offspring. Nutrients. 2018, 10(3): 292.
21. Jing Yan#, Yuyan Liu, Lujia Cao, Yuzhi Zheng, Wen Li, Guowei Huang*. Association between Duration of Maternal Folic Acid Supplementation and Postpartum Depression. Nutrients, 2017, 9(11): 1206.
22. Fei Ma#, Tianfeng Wu, jiangangzhao, Lu Ji, Aili Song, Meilin Zhang, Guowei Huang*. Plasma Homocysteine and Serum Folate and Vitamin B12 Levels in Mild Cognitive Impairment and Alzheimer’s disease: A Case-control Study. Nutrients. 2017, 9(7): 725.
23. Shanshan Cui#, Wen Li, Xin Lv, Pengyan Wang, YuxiaGao*, Guowei Huang*. Folic Acid Supplementation Delays Atherosclerotic Lesion Development by Modulating MCP1 and VEGF DNA Methylation Levels In Vivo and In Vitro. Intl J Mol Sci. 2017, 18(5): 990.
24. Xinyan Wang#, Wen Li, Shou Li, Jing Yan, John X. Wilson, Guowei Huang*. Maternal Folic Acid Supplementation During Pregnancy Improves Neurobehavioral Development in Rat Offspring. Mol Neurobiol. 2018, 55(3): 2676-2684.
研究生培养情况
博士生毕业13名，在读5名
硕士生毕业53名，在读8名
招生专业
营养与食品卫生学，公共卫生
社会兼职
1. 教育部高等学校公共卫生与预防医学类专业教学指导委员会委员
2. 第五届天津市人民政府学位委员会学科评议组成员
3. 中国营养学会常务理事
4. 中国营养学会营养与神经科学分会主委
5. 天津市营养学会副理事长
6. J Nutr Biochem 编委
7. Asia Pac J Clin Nut编委
8. 中华预防医学、营养学报编委
近5年获奖情况
1. 叶酸促进子代神经发育的作用机制及应用研究，天津市科技进步二等奖，天津市人民政府，2021.05.13，第1作者。
2. 适应性形势预防医学实践教学体系的构建及应用，国家教学成果二等奖，中华人民共和国教育部，2018.12，第1作者。
3. 作为副主编《营养与食品卫生学》（第8版），人民卫生出版社，获得全国优秀教材（高等教育类）二等奖。
获人才称号（省部级及以上）：
1. 国务院特殊津贴专家，中华人民共和国国务院（2015）。
2. 天津市杰出津门学者，天津市教育委员会（2020）。
3. 第六届天津市高等学校教学名师，天津市教育委员会（2011）。