祖述龙副教授
卫生毒理与卫生检验检疫学系
电子邮件 zushulong@tmu.edu.cn
简历
祖述龙，博士，天津医科大学副教授，主要的研究方向为病毒复制的分子机理和病毒与宿主的相互作用，以及新型疫苗的研发。已发表相关论文18篇，以第一作者发表SCI收录文章3篇，共同第一作者4篇，获得国家发明专利授权1项。
研究方向
研究病毒复制及病毒与宿主相互作用的分子机理，特别是宿主干扰素刺激基因在虫媒黄病毒的感染过程中的作用机制，以及抗黄病毒感染的药物筛选。
学习经历
1. 2008.9-2013.6 河北农业大学动物科技学院获农学学士学位
2. 2013.9-2016.6 中国农业科学院哈尔滨兽医研究所获兽医学硕士学位
3. 2016.9-2020.1 中国科学院生物物理研究所获理学博士学位
工作经历
1. 2020.6-2022.6 北京协和医学院基础医学研究所博士后
2. 2022.10-至今 天津医科大学公共卫生学院卫生毒理与卫生检验检疫学系 副教授
近五年发表文章
1 Lili Li, Meiling Gao, Jie Li, Xuping Xie, Hui Zhao, Yanan Wang, Xin Xu, Shulong Zu, Chunfeng Chen, Dingyi Wan, Jing Duan, Jingfeng Wang, Saba R. Aliyari, Sarah Gold, Jicai Zhang, Cheng-Feng Qin*,Pei-Yong Shi*, Heng Yang*, Genhong Cheng*. Identification of an immunogenic epitope and protective antibody against the furin cleavage site of SARS-CoV-2. EBioMedicine, 2023, 87: 104401.
2 Hang Chi, Lei Wang, Chanjuan Liu, Xiaohe Cheng, Hailiang Zheng, Lilang Lv, Yongcong Tan, Nana Zhang, Suoqun Zhao, Mei Wu, Dan Luo, Hongying Qiu, Rui Feng, Wangjun Fu, Jie Zhang, Xiaochuan Xiong, Yifei Zhang, Shulong Zu, Qi Chen, Qing Ye, Xintian Yan, Yuhao Hu, Zhen Zhang, Run Yan, Jiangfeng Yin, Pan Lei, Wanjing Wang, Guojun Lang*, Junbin Shao*, Yongqiang Deng*, Xiangxi Wang*, Chengfeng Qin*. An Engineered IgG–VHH Bispecific Antibody against SARS-CoV-2 and Its Variants. Small Methods, 2022, 6(12): e2200932.
3 Shulong Zu, Chunfeng Li, Lili Li, Yong-Qiang Deng, Xiang Chen, Dan Luo, Qing Ye, Yi-Jiao Huang, Xiao-Feng Li, Rong-Rong Zhang, Nina Sun, Xianqi Zhang, Saba R. Aliyari, Karin Nielsen-Saines, Jae U. Jung, Heng Yang*, Cheng-Feng Qin*, Genhong Cheng*. TRIM22 suppresses Zika virus replication by targeting NS1 and NS3 for proteasomal degradation. Cell & Bioscience, 2022, 12(1): 139.
4 Jingzhe Shang, Chunfeng Li, Zhujia Jin, Shulong Zu, Songjie Chen, Junlan Chen, Ziyi Chen, Hua Tang, Cheng-Feng Qin, Qing Ye*, Aiping Wu*. Immune profiles in mouse brain and testes infected by Zika virus with variable pathogenicity. Frontiers in Cellular and Infection Microbiology, 2022, 12: 948980.
5 Lili Li#, Meiling Gao#, Peng Jiao#, Shulong Zu#, Yong‑qiang Deng#, Dingyi Wan#, Yang Cao#, Jing Duan, Saba R. Aliyari, Jie Li, Yueyue Shi, Zihe Rao, Cheng‑feng Qin*, Yu Guo*, Genhong Cheng, Heng Yang*. Antibody engineering improves neutralization activity against K417 spike mutant SARS-CoV-2 variants. Cell & Bioscience, 2022, 12(1): 63.
6 Yong-Qiang Deng, Na-Na Zhang, Yi-Fei Zhang, Xia Zhong, Sue Xu, Hong-Ying Qiu, Tie-Cheng Wang, Hui Zhao, Chao Zhou, Shu-Long Zu, Qi Chen, Tian-Shu Cao, Qing Ye, Hang Chi, Xiang-Hui Duan, Dan-Dan Lin, Xiao-Jing Zhang, Liang-Zhi Xie, Yu-Wei Gao, Bo Ying*, Cheng-Feng Qin*. Lipid nanoparticle-encapsulated mRNA antibody provides long-term protection against SARS-CoV-2 in mice and hamsters. Cell Research, 2022, 32(4): 375-382.
7 Lishu Chen, Chao Zhou, Qi Chen, Jingzhe Shang, Zhaodan Liu, Yan Guo, Chunfeng Li, HongJiang Wang, Qing Ye, XiaoFeng Li, Shulong Zu, Fangye Li, Qing Xia, Tao Zhou, Ailing Li, Chenhui Wang, Yun Chen*, Aiping Wu*, Chengfeng Qin*, Jianghong Man*. Oncolytic Zika virus promotes intratumoral T cell infiltration and improves immunotherapy efficacy in glioblastoma. Molecular Therapy: Oncolytics, 2022, 24: 522-534.
8 Shulong Zu, Dan Luo, Lili Li, Qing Ye, Rui-Ting Li, Yanan Wang, Meiling Gao, Heng Yang*, Yong-Qiang Deng*, Genhong Cheng*. Tamoxifen and clomiphene inhibit SARS-CoV-2 infection by suppressing viral entry. Signal Transduction and Targeted Therapy, 2021, 6(1): 435.
9 Lili Li#, Meiling Gao#, Jie Li#, Shulong Zu#, Yanan Wang, Chunfeng Chen, Dingyi Wan, Jing Duan, Roghiyh Aliyari, Jingfeng Wang, Jicai Zhang, Yujie Jin, Weijin Huang, Xiaoxia Jin, Minxin Shi, Youchun Wang, Cheng-Feng Qin, Heng Yang*, Genhong Cheng*. Methods to Identify Immunogenic Peptides in SARS-CoV-2 Spike and Protective Monoclonal Antibodies in COVID-19 Patients. Small Methods, 2021, 5(7): 2100058.
10 Lili Li, Yueyue Shi, Sirui Li, Junxiao Liu, Shulong Zu, Xin Xu, Meiling Gao, Nina Sun, Chaohu Pan, Linan Peng, Heng Yang*, Genhong Cheng*. ADP-ribosyltransferase PARP11 suppresses Zika virus in synergy with PARP12. Cell & Bioscience, 2021, 11(1): 116.
11 Nina Sun, Chunfeng Li, Xiao-Feng Li, Yong-Qiang Deng, Tao Jiang, Na-Na Zhang, Shulong Zu, Rong-Rong Zhang, Lili Li, Xiang Chen, Ping Liu, Sarah Gold, Ning Lu, Peishuang Du, Jingfeng Wang*, Cheng-Feng Qin*, Genhong Cheng*. Type-IInterferon-Inducible SERTAD3 Inhibits Influenza A Virus Replication by Blocking the Assembly of Viral RNA Polymerase Complex. Cell Reports, 2020, 33(5): 108342.
12 Shulong Zu, Yong-Qiang Deng, Chao Zhou, Jie Li, Lili Li, Qi Chen, Xiao-Feng Li, Hui Zhao, Sarah Gold, Jun He, Xiang Li, Changqing Zhang, Heng Yang*, Genhong Cheng*, Cheng-Feng Qin*. 25-Hydroxycholesterol is a potent SARS-CoV-2 inhibitor. Cell Research, 2020, 30(11): 1043–1045.
13 Na-Na Zhang, Xiao-Feng Li, Yong-Qiang Deng, Hui Zhao, Yi-Jiao Huang, Guan Yang, Wei-Jin Huang, Peng Gao, Chao Zhou, Rong-Rong Zhang, Yan Guo, Shi-Hui Sun, Hang Fan, Shu-Long Zu, Qi Chen, Qi He, Tian-Shu Cao, Xing-Yao Huang, Hong-Ying Qiu, Jian-Hui Nie, Yuhang Jiang, Hua-Yuan Yan, Qing Ye, Xia Zhong, Xia-Lin Xue, Zhen-Yu Zha, Dongsheng Zhou, Xiao Yang, You-Chun Wang*, Bo Ying*, Cheng-Feng Qin*. A Thermostable mRNA Vaccine against COVID-19. Cell, 2020, 182(5): 1271-1283.e16.
14 Ziqi Zhao, Ziwei Shang, Zilton Vasconcelos, Chunfeng Li, Yisheng Jiang, Shulong Zu, Jingyi Zhang, Fengchao Wang, Li Yao, Jae U. Jung, Patricia Brasil, Maria Elisabeth Moreira, Cheng-Feng Qin, Tara Kerin, Karin Nielsen-Saines*, Genhong Cheng*, Xiaohui Zhang*, Zhiheng Xu*. Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children. Advanced Science, 2020, 7(18):1901996.
15 Chunfeng Li*, Shulong Zu, Yong-Qiang Deng, Dapei Li, Kislay Parvatiyar, Natalie Quanquin, Jingzhe Shang, Nina Sun, Jiaqi Su, Zhenyang Liu, Min Wang, Saba R. Aliyari, Xiao-Feng Li, Aiping Wu, Feng Ma, Yi Shi, Karin Nielsen-Saines, Jae U. Jung, Frank Xiao-Feng Qin, Cheng-Feng Qin*, Genhong Cheng*. Azithromycin Protects against Zika Virus Infection by Upregulating Virus-Induced Type I and III Interferon Responses. Antimicrobial Agents and Chemotherapy, 2019, 63(12): e00394-19.
16 Chunfeng#, Yong-Qiang Deng#, Shulong Zu#, Natalie Quanquin, Jingzhe Shang, Min Tian, Xue Ji, Na-Na Zhang, Hao-Long Dong, Yan-Peng Xu, Ling-Zhai Zhao, Fu-Chun Zhang, Xiao-Feng Li, Aiping Wu, Genhong Cheng*, Cheng-Feng Qin*. Zika virus shedding in the stool and infection through the anorectal mucosa in mice. Emerging Microbes & Infections, 2018, 7(1): 169.
17 Xingliang Zhu#, Chunfeng Li#, Shabbir Khan Afridi#, Shulong Zu#, Jesse W. Xu, Natalie Quanquin, Heng Yang, Genhong Cheng*, Zhiheng Xu*. E90 subunit vaccine protects mice from Zika virus infection and microcephaly. Acta Neuropathologica Communications, 2018, 6(1): 77.
18 秦成峰，杨衡，邓永强，李晓峰，赵慧，祖述龙，张娜娜，胆固醇-25-羟化酶及其酶促产物在制备抑制新型冠状病毒药物中的用途（发明专利，ZL 202110267601.9）
获奖情况
2020-2021年度苏州市自然科学优秀学术论文三等奖