Xin Qiao, Ph.D.

Xin Qiao, PhD

Assistant Professor

Department of Chemical Biology

School of Pharmacy

Tianjin Medical University

22 Qixiangtai Road

Tianjin 300070

Phone: +86-22-83336681

Email: qiaoxin@tmu.edu.cn

Education

BS     Tianjin Medical University, Tianjin, China, 2008

Ph.D.  Tianjin Medical University, Tianjin, China, 2013

Professional Experience

2013-            Assistant Professor, Department of Chemical Biology, Tianjin Medical University, Tianjin, China 2011-2013    Visiting Ph.D. Student, Department of Chemistry, Wake Forest University, NC, United States

Honors

2016   Annual Excellent Class Tutor of Tianjin Medical University.

2015   First Prize of Excellent Papers of Academic Annual Meeting of Tianjin Medical University.

2014   Third Level Talent of Tianjin “131” Innovative Talents Training Program.

2012   Awardee of National Graduate Students’ Scholarship.

2011   Awardee of State Scholarship Fund by China Scholarship Council (No.2011694010).

2010   Awardee of Innovation Grant for Graduate Students of Tianjin Medical University (No.2010GSI05).

2009   Awardee of Excellent Student Cadre in Tianjin City, Tianjin, China.

Professional Service

Reviewer for:

Metallomics 

Journal of Photochemistry & Photobiology, B: Biology

Membership of Academic Society

Member of the Chinese Chemical Society (CCS)

Publication 

[1] H Tian, X Qiao (co-first author), CZ Xie, Y Ouyang* and JY Xu*. Synthesis, characterization, and magnetochemical properties of two Mn-4 clusters derived from 2-pyridinecarboxaldehyde Schiff base ligands. J Coord Chem 2017; 70: 1207-1220. (IF = 2.012)

[2] WJ Lian, XT Wang, CZ Xie, H Tian, XQ Song, HT Pan, X Qiao* and JY Xu*. Mixed-ligand copper(II) Schiff base complexes: the role of the co-ligand in DNA binding, DNA cleavage, protein binding and cytotoxicity. Dalton Trans 2016; 45: 9073-9087. (IF = 4.197)

[3] X Qiao, S Ding, F Liu, GL Kucera, and U Bierbach*. Investigating the cellular fate of a DNA-targeted platinum-based anticancer agent by orthogonal double-click chemistry. J Biol Inorg Chem 2014; 19: 415-426. (IF = 2.583)

[4] X Qiao, ZY Ma, J Shao, WG Bao, JY Xu*, ZY Qiang and JS Lou*. Biological evaluation of a cytotoxic 2-substitued benzimidazole copper(II) complex: DNA damage, antiproliferation and apoptotic induction activity in human cervical cancer cells. Biometals 2014; 27: 155-172. (IF = 2.503)

[5] S Ding, X Qiao (co-first author), J Suryadi, GS Marrs, GL Kucera, and U Bierbach*. Using fluorescent post-labeling to probe the subcellular localization of DNA-targeted platinum. Angew Chem Int Ed 2013; 52: 3350-3354. (IF = 11.261)

[6] X Qiao, AE Zeitany, MW Wright, AS Essader, KE Levine, GL Kucera and U Bierbach*. Analysis of the DNA damage produced by a platinum acridine antitumor agent and its effects in NCI-H460 lung cancer cells. Metallomics 2012; 4: 645-652 (Back cover paper). (IF = 3.585)

[7] X Qiao, ZY Ma, CZ Xie, F Xue, YW Zhang, JY Xu*, ZY Qiang*, JS Lou, GJ Chen and SP. Yan. Study on potential antitumor mechanism of a novel Schiff base copper(II) complex: synthesis, crystal structure, DNA binding, cytotoxicity and apoptosis induction activity. J Inorg Biochem 2011; 105: 728-737. (IF = 3.444)

[8] S Ding, X Qiao, GL Kucera and U Bierbach*. Design of a platinum–acridine–endoxifen conjugate targeted at hormone-dependent breast cancer. Chem Commun 2013; 49: 2415-2417. (IF = 6.834)

[9] S Ding, X Qiao, GL Kucera and U Bierbach*. Using a build-and-click approach for producing structural and functional diversity in DNA-targeted hybrid anticancer agents. J Med Chem 2012; 55: 10198-10203. (IF = 5.447)

[10] ZY Ma, X Qiao, CZ Xie, J Shao, JY Xu*, ZY Qiang and JS Lou*. Activities of a novel Schiff Base copper(II) complex on growth inhibition and apoptosis induction toward MCF-7 human breast cancer cells via mitochondrial pathway. J Inorg Biochem 2012; 117: 1-9. (IF = 3.444)

[11] GJ Chen, X Qiao, CY Gao, GJ Xu, ZL Wang, JL Tian*, JY Xu, W Gu, X Liu and SP Yan*. Synthesis, DNA binding, photo-induced DNA cleavage and cell cytotoxicity studies of a family of light rare earth complexes. J Inorg Biochem 2012; 109: 90-96. (IF = 3.444)

[12] CY Gao, X Qiao, ZY Ma, ZG Wang, J Lu, JL Tian*, JY Xu and SP Yan*. Synthesis, characterization, DNA binding and cleavage, BSA interaction and anticancer activity of dinuclear zinc complexes. Dalton Trans 2012; 41: 12220-12232. (IF = 4.197)

[13] GJ Chen, X Qiao, PQ Qiao, GJ Xu, JY Xu, JL Tian*, W Gu and SP Yan*. Synthesis, DNA binding, photo-induced DNA cleavage, cytotoxicity and apoptosis studies of copper (II) complexes. J Inorg Biochem 2011; 105: 119-126. (IF = 3.444)

[14] GJ Chen, X Qiao, JL Tian*, JY Xu, W Gu, X Liu and SP Yan*. Synthesis, DNA binding, photo-induced DNA cleavage and cytotoxicity studies of europium(III) complexes. Dalton Trans 2010; 39: 10637-10643. (IF = 4.197)

[15] CZ Xie, X Qiao, F Xue and JY Xu*. Poly[[bis[μ3-5-carboxy-2,2’-bipyridine-5’-carboxylato -k4O:O’:N,N’] lead(II)]. Acta Cryst C 2009; m491-m493. (IF = 0.326)

[16] JY Xu, X Qiao, HB Song, SP Yan*, DZ Liao, S Gao, Y Journaux* and J Cano. Self-assembly and magnetic properties of a Ni(II)₈(4-hydroxo)₆ cube with 2-pyrazolate as exogeneous anchillary ligand. Chem Commun 2008; 6414-6416. (IF = 6.834)

[17] Y Ouyang, XF Zhao, X Qiao, R Zhang, WG Bao, CZ Xie and JY Xu*. A mononuclear nickel(II) complex based on polypyridyl ligand: synthesis, characterization, and biological activity. J Coord Chem 2016; 69: 475-484. (IF = 2.012)

[18] M Yang, AJ Pickard, X Qiao, MJ Gueble, CS Day, GL Kucera and U Bierbach*. Synthesis, reactivity and biological activity of gold(I) complexes modified with thiourea-functionalized tyrosine kinase inhibitors. Inorg Chem 2015; 54: 3316-3324. (IF = 4.762)

[19] J Shao, WG Bao, H Tian, B Li, XF Zhao, X Qiao, and JY Xu*. Nuclease activity and protein-biding properties of a novel tetranuclear thiosemicarbazide Pt(II) complex. Dalton Trans 2014; 43: 1663-1671. (IF = 4.197)

[20] CZ Xie, MM Sun, SH Li, XT Zhang, X Qiao, Y Ouyang and JY Xu*. Synthesis, characterization, DNA interaction, cytotoxicity, and apoptosis induction of a mixed-ligand copper(II) complex. J Coord Chem 2013; 66: 3891-3905. (IF = 2.012)

[21] GJ Chen, ZG Wang, X Qiao, JY Xu, JL Tian*, SP Yan*. Synthesis, DNA binding, photo-induced DNA cleavage, cytotoxicity studies of a family of heavy rare earth complexes. J Inorg Biochem 2013; 127: 39-45. (IF = 3.444)

[22] JY Xu*, HB Song, GF Xu, X Qiao, SP Yan*, DZ Liao, Y Journaux* and J Cano. A new enneanuclear nickel(II) cluster with a rectangular face-centered trigonal prism structure and cluster glass behavior. Chem Commun 2012; 1015-1017. (IF = 6.834)

[23] F Xue, CZ Xie, YW Zhang, Z Qiao, X Qiao, JY Xu* and SP Yan. Two new dicopper(II) complexes with oxamido-bridged ligand: Synthesis, crystal structures, DNA binding/cleavage and BSA binding activity. J Inorg Biochem 2012; 115: 78-86. (IF = 3.444)

[24] YZ Liu, QJ Su, X Qiao, CZ Xie, Y Ouyang, JY Xu*, DZ Liao and SP Yan*. Synthesis, crystal structure and magnetic property of 4,4’-bipyridine bridged dinuclear Mn(II) and Ni(II) complexes containing BMA (BMA = N, N-bis(benzimidazol -2-yl-methyl)amine). Z Anorg Allg Chem 2010; 36: 600-604. (IF =1.160)

Grant

Ongoing:

National Natural Science Foundation of China (No.21401141) (as P.I.)

Project: Establishing, Biological Evaluation and Cellular Imaging of Platinum-based RNA Polymerase I Selective Inhibitors Based on a “Build-and-Click” Approach.

Period: 01/01/2014−12/31/2017

Tianjin Municipal Natural Science Foundation (No.17JCYBJC28500) (as P.I.)

Project: Design, Synthesis and Anticancer Activity Studies of Novel Platinum (IV) Prodrugs Based on RNA Polymerase I Selective Inhibitors.

Period: 04/01/2017−03/31/2020

Completed:

Innovation Grant for Graduate Students of Tianjin Medical University (No.2010GSI05)

Project: Study on Synthesis, Characterization and Biological Evaluation of Schiff Base Metal Complexes.

Period: 07/01/2010−06/30/2013