Shao-Yong Li, Ph.D.
Shao-Yong Li, PhD
Professor
School of Pharmacy
Tianjin Medical University
22 Qixiangtai Road
Tianjin 300070
Phone: +86-22-83336659-815
Email: lishaoyong@tmu.edu.cn
Education
2002.9-2005.7 PhD, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
Professional Experience
2005.12- Professor, Associate Professor, Assistant Professor, Department of Pharmacy, Tianjin Medical University, Tianjin, China
2009.2-2010.1 Postdoctoral Fellow, Mississippi State University, Starkville, MS, USA
2010.2-2010.6 Postdoctoral Fellow, Michigan Technological University, Houghton, MI,USA
Research Interest
1. The application of bridging chiral calix[4]arene catalysts in asymmetrical synthesis of chiral drugs.
Chiral organocatalysts as low-molecular-weight organic molecules are readily available, stable and inexpensive. Bridging chiral calix[4]arenes, which originate from asymmetric substitution on the calix[4]arene methylene bridge, have a potential to grow up as outstanding chiral catalysts and a huge application prospect in chiral drug synthesis.
2. Study on antibacterial drugs based on bridge-substituted calix[4]arene derivatives.
The cell membrane of microorganisms plays key roles on supporting the structure and morphology, and maintains the material entry and exit and molecular exchange between internal and external environment. The amphiphilic bridge-substituted calix[4]arene derivatives can insert into and damage bacterial membranes to thus facilitate the leakage of intracellular contents, such as metals, proteins, lipids and nucleic acid.
3. Study on anti rheumatoid arthritis drugs.
The chemical components with anti rheumatoid arthritis activity were isolated, purified and screened from natural origins. Then their action mechanism was studied in vivo and in vitro. Under the guidance of computer-aided drug design, they will be rationally modified to prepare the derivatives with higher activity, and finally obtain drugs for rheumatoid arthritis treatment.
Professional Service
Reviewer for:
Organic Letters, Journal of Organic Chemistry, Chemical Communications, New Journal of Chemistry, RSC Advances, Synthesis, etc.
Membership of Academic Society
Chinese Chemical Society (CCS)
1. Dong-Li Zhang, Yue Wang, Jing-Bo Liu, Qian Chen, Shao-Yong Li, De-Jun Jin,* Sheng-An Tang.* Dichapetalin-type triterpenoids from Dichapetalum longipetalum and their anti-inflammatory activity. Phytochemistry, 2024, 217, 113900.
2. Xin-Ao Li, Yi-Meng Zhang, Jian-Feng Huang, Chao-Ping Hou, Shao-Yong Li, Li-Min Xiao, Jun-Min Liu.* A direct Z-scheme quasi-2D/2D heterojunction constructed by loading photosensitive metal–organic nanorings with Pd single atoms on graphitic–C3N4 for superior visible light-driven H2 production. Solar RRL, 2023, 7, 2300148.
3. Xiaopu Jia, Shuai Fan, Weili Dong, Shaoyong Li, Yan Zhang, Ying Ma, Shuqing Wang. Setmelanotide optimization through fragment-growing, molecular docking in-silico method targeting MC4 receptor. Journal of Biomolecular Structure & Dynamics, 2023, 41, 15411-15420.
4. Ying-Hong Ma#, Yu Yu#, Shuai Fan, Xiao-Pu Jia, Sheng-An Tang, Shu-Qing Wang,* Wei-Li Dong*, Shao-Yong Li*. Calix[4]arene bridge mononitration with tert-butyl nitrite: synthesis of bridging chiral p-tert-butylcalix[4]arene with a mononitro bridge substituent. The Journal of Organic Chemistry, 2022, 87, 7665-7672.
5. Ting-Ting Ding#, Ya-Ya Liu#, Li-Ming Zhang, Jia-Rui Shi, Wei-Ren Xu, Shao-Yong Li,* Xian-Chao Cheng.* Exploring dual agonists for PPARα/γ receptors using pharmacophore modeling, docking analysis and molecule dynamics simulation. Combinatorial Chemistry & High Throughput Screening, 2022, 25, 1450-1461.
6. Fuhang Song#, Jiansen Hu#, Xinwan Zhang, Wei Xu, Jinpeng Yang, Shaoyong Li and Xiuli Xu.* Unique cyclized thiolopyrrolones from the marine-Derived Streptomyces sp. BTBU20218885. Marine Drugs. 2022, 20, 214.
7. Pengfei Jin, Min Li, Shaoyong Li, Hongquan Yin, Shengan Tang. * Study on chemical constituents in Ferula feruloides. Transactions of Beijing Institute of Technology, 2022, 42 (2), 215-222.
8. Chao-Ping Hou, Xin-Lun Chen, Zhi-Jian Huang, Yang Lei, Li-Min Xiao, Jian-Feng Huang,* Shao-Yong Li,* Jun-Min Liu.* Robust heterogeneous photocatalyst for visible-light-driven hydrogen evolution promotion: immobilization of a fluorescein dye-encapsulated metal-organic cage on TiO2. ACS Applied Materials & Interfaces. 2021, 13, 57230-57240.
9. Fan Zhang, Yuan Jiang, Pan Jiao, Shaoyong Li,∗ Cheng Tang.∗ Ligand fishing via a monolithic column coated with white blood cell membranes: a useful technique for screening active compounds in Astractylodes lancea. Journal of Chromatography A, 2021, 1656, 462544.
10. Dong-Li Zhang, Min Li, Gui-Fang Han, Shao-Yong Li,* De-Jun Jin,* Sheng-An Tang.* Longipetalol A: ahighly modified triterpenoid from Dichapetalum longipetalum. Journal of Natural Products. 2021, 84, 1556-1562.
11. Dong-Li Zhang, Min Li, Wen-Feng Xu, Huan Yu, Peng-Fei Jin, Shao-Yong Li,* Sheng-An Tang.* Nine new dichapetalin-type triterpenoids from the twigs of Dichapetalum gelonioides (Roxb.) Engl. Fitoterapia, 2021, 151, 104868.
12. Xin-Bang Peng#, Di He#, Guan-Nan Sun, Yu Yu, Ying-Hong Ma, Sheng-An Tang,* Wei-Li Dong,* Shao-Yong Li.* Mononitration of a calix[4]arene methylene bridge: synthesis and preliminary catalysis performances of bridging chiral p-tert-butylcalix[4]arenes with a monoamino bridge substituent in a 1,3-alternate conformation. Journal of Organic Chemistry,2021, 86, 3952-3959.
13. Hao Ma#, Xiu-Fang Weng#, Shan-Shan Ren, Zi-Ying Tang, Xin-Bang Peng, Yong He, Shuang Zheng,* Wei-Li Dong,* Shao-Yong Li.* Synthesis of bridging chiral p-tert-butylcalix[4]arenes with one and two carbamoyl bridge-substituents through anionic ortho-Fries rearrangement. ChemistrySelect, 2020, 5, 6274-6277.
14. Chunhui Gao#, Yinghua Zhang#, Yan Zhang, Shaoyong Li, Xinlin Yang, Yan Chen, Jingwei Fu, Yinsong Wang*, Xiaoying Yang.* cRGD-modified and disulfide bond-crosslinked polymer nanoparticles based on iopamidol as a tumor-targeted CT contrast agent. Polymer Chemistry, 2020, 11, 889-899.
15. Yingchun Li, Weixiang Zhai, Yongfang Liao, Jiangping Nie, Guifang Han, Yuguang Song, Shaoyong Li, Jingli Hou,* Yangping Liu.* Synthesis of central cirality-containing triarylmethanols and triarylmethyl radicals with extraordinarily stable configurations. Journal of Organic Chemistry,2019, 84, 11774-11782.
16. Hao Ma#, Yong He#, Xiu-Fang Weng, Sheng-An Tang, Jiu-Xing Yan, Shao-Yong Li,* Wei-Li Dong,* Shi-Kun Ma.* Design and synthesis of bridging chiral p-t-butylcalix[4]arene tetrahydroisoquinolines and their application in Henry reaction as chiral organocatalysts. ChemistrySelect, 2019, 4, 4642-4646.
17. D. Hua, W. Luo, J. Duan, D. Jin, X. Zhou, C. Sun, Q.Wang, C. Shi, Z. Jiang, R.Wang, C. Rao, S. Yu,*S. Li,* S. Tang*. Screening and identification of potent α-glycosidase inhibitors from Gardenia jasminoides Ellis. South African Journal of Botany, 2018, 119, 377-382.
18. Wen-Shan Liu, Di He, Hao Ma, Xiu-Fang Weng, Shan-Shan Ren, Xiong Liu, Sheng-An Tang, Shi-Kun Ma, Jun-Min Liu, Shao-Yong Li.* Bridging chiral de-tert-butylcalix[4]arenes: diastereomeric crystallization-based optical resolution and determination of absolute configuration. ChemistrySelect, 2018, 3, 10153-10156.
19. Jun-Fang Wang, Li-Yuan Huang, Jian-Hua Bu, Shao-Yong Li, Su Qin, Yao-Wei Xu, Jun-Min Liu,* Cheng-Yong Su. A fluorescent calixarene-based dimeric capsule constructed via a MII–terpyridine interaction: cage structure, inclusion properties and drug release. RSC Advances, 2018,8, 22530-22535.
20. Weixiang Zhai, Yalan Feng, Huiqiang Liu, Antal Rockenbauer*, Deni Mance, Shaoyong Li, Yuguang Song,* Marc Baldus, Yangping Liu.* Diastereoisomers of L-proline-linked tritylnitroxide biradicals: synthesis and effect of chiral configurations on exchange interactions. Chemical Science, 2018, 9, 4381-4391.
21. Chuan Zhao, Jiao-Jiao Xu, Jia Wang, Shao-Yong Li, Wei Qiao, Sheng-An Tang.* Five new cembrane diterpenoids from the South China Sea soft coral Sinularia flexibilis. Phytochemistry Letters, 2018, 25, 180-183.
22. Wang Ran-ran, Li Shao-yong, Qiao Wei, * Song Fang-qin, Zhou Hui, Qiao Shan. The mechanism of active ingredients in Salicornia europaea in treatment of diabetes based on pharmacological network. Chinese Traditional Patent Medicine, 2018, 40(4), 802-809.
23. Ming-Liang Chang, Yong He, Jing Zhou,* Shao-Yong Li.* Synthesis of N,O-type inherently chiral calix[4]arenes substituted on the lower rim and their organocatalysis properties. Journal of the Brazilian Chemical Society, 2017, 28, 1363-1370.
24. Ming-Liang Chang, Yong He, Chuan Zhao, Lan-Fang Hao, Shao-Yong Li.* Four types of novel potential malate synthase inhibitors from virtual screening. Current Enzyme Inhibition, 2017, 13, 176-183.
25. Wen-Qiang Xu, Wen-Shan Liu, Jiu-Xing Yan, Shi-Kun Ma, Jing Guo, Jun-Min Liu,* Run-Ling Wang,* Shao-Yong Li.*An approach to optically pure bridging chiral p-tert-butylcalix[4]arenes through a homologous anionic ortho-Fries rearrangement. Journal of Organic Chemistry,2016, 81, 10683-10687.
26. Xinghua Liu, Chunhui Gao, Junheng Gu, Yunfang Jiang, Xinlin Yang, Shaoyong Li, Wei Gao, Tong An, Hongquan Duan, Jingwei Fu, Yinsong Wang,* Xiaoying Yang.* Hyaluronic acid stabilized iodine-containing nanoparticles with Au nanoshell coating for X‑ray CT imaging and photothermal therapy of tumors. ACS Applied Materials & Interfaces,2016, 8, 27622-27631.
26. Xu-Dong Lin, Biao Peng, Shao-Yong Li, Jia Shao, Qing-Zhong Li, Cheng-Zhi Xie,* Jing-Yuan Xu.* Novel Zn(II)-thiazolone-based solid fluorescent chemosensors: naked-eye detection for acid/base and toluene. RSC Advances, 2016, 6, 52310-52317.
28. Feng-Jing An, Wen-Qiang Xu, Shuang Zheng, Shi-Kun Ma, Shao-Yong Li,* Run-Ling Wang,* Jun-Min Liu*. Bridging chiral calix[4]arenes: description, optical resolution, and absolute configuration determination. European Journal of Organic Chemistry, 2016, 1012-1016.
29. Li-Lin Tan, Jun-Min Liu,* Shao-Yong Li, Li-Min Xiao, Dai-Bin Kuang, Cheng-Yong Su.* Dye-sensitized solar cells with improved performance using cone-calix[4]arene based dyes. ChemSusChem, 2015, 8, 280-287.
30. Yao-Wei Xu, Li-Lin Tan, Jun-Min Liu,* Li-Min Xiao, Shao-Yong Li,* Cheng-Yong Su.* Fluorescent calix[4]arene chemosensor for acidic and basic amino acids in pure aqueous media. RSC Advances, 2014, 4, 28046-28051.
31. Shuang Zheng, Ming-Liang Chang, Jing Zhou, Jing-Wei Fu, Qing-Wei Zhang, Shao-Yong Li,* Wei Qiao,* Jun-Min Liu.* Qualitative analysis of the helical electronic energy of inherently chiral calix[4]arenes: an approach to effectively assign their absolute configuration. International Journal of Molecular Sciences,2014,15, 9844-9858.
32. Shao-Yong Li, Yao-Wei Xu, She-Quan Zeng, Li-Min Xiao, Hong-Quan Duan, Xue-Lian Lin, Jun-Min Liu,* Cheng-Yong Su.* Highly selective fluorescent calix[4]arene chemosensor for acidic amino acids in pure aqueous media. Tetrahedron Letters, 2012, 53, 2918-2921.
33. Jun-Min Liu,* Jian-Ying Shi, Yao-Wei Xu, Cheng-Yong Su, Shao-Yong Li.* Synthesis of inherently chiral wide rim ABC-substituted calix[6]arene derivatives. Supramolecular Chemistry, 2011, 23, 419-424.
34. Shao-Yong Li, Yao-Wei Xu, Jun-Min Liu,* Cheng-Yong Su. Inherently chiral calixarenes: synthesis, optical resolution, chiral recognition and asymmetric catalysis.International Journal of Molecular Sciences,2011,12, 429-455.
35. Dongmao Zhang,* Karthikeshwar Vangala, Shaoyong Li, Michael Yanney, Hao Xia, Sige Zou, Andrzej Sygula. Acid cleavable surface enhanced raman tagging for protein detection. Analyst,2011,136, 520-526.
Grants
Ongoing:
1. Study of supramolecular catalysts of bridging chiral calix[4]arene spiropyrrolidines. NSFC (Grant No. 22171211). PI.
Completed:
1. The design and synthesis of novel calixarene-based dyes and application for efficient dye-sensitized solar cells. NSFC (Grant No. 21572280). Co-PI.
2. The study of intrinsically chiral calix[4]arene catalysts applied in asymmetrical synthesis of chiral 2-amino-1-aryl ethanol drugs under the guidance of helix electronic theory. NSFC (Grant No. 21272173). PI.
3. The construction and properties of supramolecular capsules based on UPy/NAPy combination. NSFC (Grant No. 91227105). Co-PI.
4. The synthesis and chiral extraction properties of fluorescent sensors for chiral drugs. Tianjin Medical University (Grant No. 2006x9d2). PI.
