Huabing Sun, Ph.D
Huabing Sun, Ph.D
Professor
School of Pharmacy
Tianjin Medical University
22 Qixiangtai Road
Tianjin 300070
Phone: +86-18526061286
Email: sunhuabing@tmu.edu.cn
Education
B.S. Tianjin University of Science & Technology, Tianjin, China, 2007
M.S. Nankai University, Tianjin, China, 2010
Ph.D University of Wisconsin-Milwaukee, Milwaukee, USA, 2015
Professional Experience
2015-2016 Faculty Assistant, University of Wisconsin-Milwaukee, Milwaukee, USA
2016-2019 Postdoctoral Fellow, Department of Chemistry, Johns Hopkins University, Baltimore, USA
2019- Professor, School of Pharmacy, Tianjin Medical University, Tianjin, China
Honors
1. Tianjin Distinguished Professor Young Scholar, Tianjin, China 2020
2. Excellent Talent Project, Tianjin Medical University, China 2019
Reviewer for:
ACS Sensors, Chemical research in toxicology, RSC Advances, Bioorganic & Medicinal Chemistry,
Tetrahedron.
Publication
18. X. Yan, Y. Gao, H. Liu, X. Qiao, C. Xie*, Q. Li, W. Gao, H. Sun*, J. Xu*. A novel double target fluorescence probe for Al3+/Mg2+ detection with distinctively different responses and its applications in cell imaging. Spectrochim. Acta A Mol. Biomol. Spectrosc.2021, 261, 120067.
17. H. Fan, H. Sun, Q. Zhang, X. Peng*. Photoinduced DNA Interstrand Cross‐Linking by 1, 1′‐Biphenyl Analogues: Substituents and Leaving Groups Combine to Determine the Efficiency of Cross‐Linker. Chem. Eur. J.2021, 27, 5215-5224.
16. A. Korman+, H. Sun+, B. Hua, H. Yang, J. N. Capilato, R. Paul, S. Panja, T. Ha, M. M. Greenberg*, S. A. Woodson*. Light-Controlled Twister Ribozyme with Single-Molecule Detection Resolves RNA Function in Time and Space. Proc. Natl. Acad. Sci. USA, 2020, 117, 12080-12086. (+: Equal Contribution)
15. H. Sun, L. Zheng, K. Yang, M. M. Greenberg*. Positional Dependence of DNA Hole Transfer Efficiency in Nucleosome Core Particles. J. Am. Chem. Soc.2019, 141, 10154-10158.
14. H. Fan+, H. Sun+, M. M. Haque, X. Peng*. Effect of Triazole-Modified Thymidines on DNA and RNA Duplex Stability. ACS Omega,2019, 4, 5107-5116. (+: Equal Contribution)
13. K. Yang, H. Sun, L. Lowder, S. Varadarajan*, M. M. Greenberg*. Reactivity of N3-Methyl-2′-Deoxyadenosine in Nucleosome Core Particles.Chem. Res. Toxicol. 2019, 32, 2118-2124.
12. H. Sun+, L. Zheng+, M. M. Greenberg*.Independent Generation of Reactive Intermediates Leads to an Alternative Mechanism for Strand Damage Induced by Hole Transfer in Poly(dA-T) Sequences. J. Am. Chem. Soc.2018, 140, 11308-11316. (+: Equal Contribution)
11. H. Fan, H. Sun, X. Peng*. Substituents Have a Large Effect on Photochemical Generation of Benzyl Cations and DNA Cross‐Linking. Chem. Eur. J.2018, 24, 7671-7682.
10. W. Chen+, H. Fan+, K. Balakrishnan, Y. Wang, H. Sun, Y. Fan, V. Gandhi, L. A. Arnold, X. Peng*. Discovery and Optimization of Novel Hydrogen Peroxide Activated Aromatic Nitrogen Mustard Derivatives as Highly Potent Anticancer Agents. J. Med. Chem.2018,61, 9132-9145.
9. H. Sun, M. L. Taverna Porro, M. M. Greenberg*. Independent Generation and Reactivity of Thymidine Radical Cations. J. Org. Chem. 2017, 82, 11072-11083.
8. Y. Wang+, H. Fan+, K. Balakrishnan, Z. Lin, S. Cao, W. Chen, Y. Fan, Q. A. Guthrie, H. Sun, K. A. Teske, V. Gandhi, L. A. Arnold, X. Peng*. Hydrogen Peroxide Activated Quinone Methide Precursors with Enhanced DNA Cross-Linking Capability and Cytotoxicity towards Cancer Cells. E. J. Med. Chem.2017, 133, 197-207.
7. H. Sun+, H. Fan+, H. Eom, X. Peng*. Coumarin-Induced DNA Ligation, Rearrangement to DNA Interstrand Crosslinks, and Photorelease of Coumarin Moiety. ChemBioChem, 2016, 17, 2046-2053. (+: Equal Contribution)
6. Y. Han, W. Chen, Y. Kuang, H. Sun, Z. Wang, X. Peng*. UV-Induced DNA Interstrand Cross-Linking and Direct Strand Breaks from a New Type of Binitroimidazole Analogue. Chem. Res. Toxicol.2015, 28, 919-926.
5. H. Sun, H. Fan, X. Peng*. Quantitative DNA interstrand cross-link formation by coumarin and thymine: structure determination, sequence effect, and fluorescence detection. J. Org. Chem. 2014, 79, 11359-11369.
4. M. M. Haque, H. Sun, S. Liu, Y. Wang, X. Peng*. Photoswitchable Formation of a DNA Interstrand Cross-Link by a Coumarin‐Modified Nucleotide. Angew. Chem. Int. Ed.2014, 53, 7001-7005.
3. J. Zhao, H. Sun, L. Liu, W. Chang, J. Li*. Synthesis, Characterization and Potential Electrochemical Properties of Novel Mn-Re Dinuclear Complexes Containing N-Heterocyclic Carbene-carbon Disulfide Ligands. Chem. J. Chinese U.2014, 35, 68-74. (Chinese)
2. H. Sun, X. Peng*. Template-Directed Fluorogenic Oligonucleotide Ligation using “Click” Chemistry: Detection of Single Nucleotide Polymorphism in the Human p53 Tumor Suppressor Gene. Bioconjugate Chem.2013, 24, 1226-1234.
1. Y. Kuang, H. Sun, J. C. Blain, X. Peng*. Hypoxia-Selective DNA Interstrand Cross-Link Formation by Two Modified Nucleosides. Chem. Eur. J.2012, 18, 12609-12613.
Grant
Ongoing:
1. National Natural Science Foundation of China, 22007072, 2021.01.01-2023.12.31
2.The Science & Technology Development Fund of Tianjin Education Commission for Higher Education, 2020ZD15, 2020.12-2023.11
3. Tianjin Distinguished Professor Young Scholar Project, 2020.12-2025.11
4. Excellent Talent Project of Tianjin Medical University, 2019.07-2024.06
