Heli Fan, Ph.D
Heli Fan, Ph.D
Instructor
School of Pharmacy
Tianjin Medical University
22 Qixiangtai Road
Tianjin 300070
Phone: +86-18822388405
Email: helifan@tmu.edu.cn
Research Inteaest
Photo-inducible DNA interstrand crosslinking agents
Development of potential targetedantitumor drugs
Chemical biology study of nucleosome core particles
Education
B.S. Liaocheng University, Shandong, China, 2007
M.S. Nankai University, Tianjin, China, 2010
Ph.D University of Wisconsin-Milwaukee, Milwaukee, USA, 2018
Professional Experience
2019.1-2019.5 Postdoctoral Fellow, Department of Chemistry, University of Wisconsin-Milwaukee, Milwaukee, USA
2019.6-2020.9 Research Assistant, School of Pharmacy, Tianjin Medical University, Tianjin, China
2020.10- Instructor, School of Pharmacy, Tianjin Medical University, Tianjin, China
Publication
1. H. Fan #, M. A. Uz Zaman#, W. Chen#, T. Ali, A. Campbell, Q. Zhang, N. I. Setu, E. Saxon, N. M. Zahn, A. M. Benko, L. A. Arnold, X. Peng.* Assessment of Phenylboronic Acid Nitrogen Mustards as Potent and Selective Drug Candidates for Triple-Negative Breast Cancer, ACS Pharmacol. Transl. Sci.2021, 4, 687–702.(Co-first author)
2. H. Fan, H. Sun, Q. Zhang, X. Peng.* Photoinduced DNA Interstrand Cross‐linking by 1,1’‐Biphenyl Analogues: Substituents and Leaving Groups Combine to Determine the Efficiency of Cross‐Linker, Chem. Eur. J.2021, 27, 5215–5224.
3. H. Fan, X. Peng.* Photoinduced DNA Interstrand Cross-Linking by Benzene Derivatives: Leaving Groups Determine the Efficiency of the Cross-Linker. J. Org. Chem.2021, 86, 493–506.
4. H. Fan#, H. Sun#, M. M. Haque, X. Peng.* Effect of Triazole-Modified Thymidines on DNA and RNA Duplex Stability. ACS Omega.2019, 4, 5107−5116. (Co-first author)
5. W. Chen#, H. Fan#, K. Balakrishnan, Y. Wang, H. Sun, Y. Fan, V. Gandhi, L. A. Arnold, X. Peng.* Discovery and Optimization of Novel Hydrogen Peroxide Activated Aromatic Nitrogen Mustard Derivatives as Highly Potent Anticancer Agents. J. Med. Chem.2018, 61, 9132−9145.(Co-first author)
6. Z. Lin#, H. Fan#, Q. Zhang, X. Peng.* Design, Synthesis, and Biological Investigation of New Binaphthalene Precursors as Efficient Photo-Activated DNA Interstrand Cross-Linkers. J. Org. Chem.2018, 83, 8815−8826.(Co-first author)
7. H. Fan, H. Sun, X. Peng.* Substituents Have a Large Effect on Photochemical Generation of Benzyl Cations and DNA Cross-Linking. Chem. Eur. J.2018, 24, 7671–7682.
8. Y. Wang#, H. Fan#, K. Balakrishnan, Z. Lin, S. Cao, W. Chen, Y. Fan, Q. A. Guthrie, H. Sun, K. A. Teske, V. Gandhi, L. A. Arnold, X. Peng.* Hydrogen Peroxide Activated Quinone Methide Precursors with Enhanced DNA Cross-Linking Capability and Cytotoxicity towards Cancer Cells. Eur J Med Chem.2017, 133, 197–207.(Co-first author)
9. H. Sun#, H. Fan#, H. Eom, X. Peng.* Coumarin-Induced DNA Ligation, Rearrangement to DNA Interstrand Cross-Links, and Photo-Release of Coumarin Moiety. ChemBioChem.2016, 17, 2046–2053.(Co-first author)
10. Y. Wang, Z. Lin, H. Fan, X. Peng.* Photo-Induced DNA Interstrand Cross-Link Formation by Naphthalene Boronates via a Carbocation. Chem. Eur. J.2016, 22, 10382–10386.
11. H. Fan, X. Peng.* “Novel DNA Cross-Linking Agents and Their Applications” in “Advances in Molecular Toxicology Volume 10”, Ed. J. Fishbein, Elsevier. 2016, 10, 235-292.(Book Chapter)
12. H. Sun, H. Fan, X. Peng.* Quantitative DNA Interstrand Cross-link Formation by Coumarin and Thymine: Structure Determination, Sequence Effect, and Fluorescence Detection. J. Org. Chem.2014, 79, 11359–11369.
Grant
Ongoing:
The Science & Technology Development Fund of Tianjin Education Commission for Higher Education, 2020ZD15, 2020.12-2023.11 (participant)
