Guowei Huang, MD, PhD,Professor

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Guowei Huang Professor

Department of Nutrition and Food Science


Emailhuangguowei@tmu.edu.cn


Resume


Research direction

Major research interests lie in the field of the nutrition and neuroscience, nutrition and chronic diseases.


Education

BD Tianjin Medical University, Tianjin, China, 1986

MD  Tianjin Medical University, Tianjin, China, 1989

Ph.D.Tianjin University of Science and Technology, Tianjin, China, 2009


Professional Experience

2005-  Professor, School of Public Health, Tianjin Medical University, Tianjin, China

2003-2004 Visiting Professor, Faculty of Medicine and Dentistry, University of Western Ontario, Canada

2000-2005 Professor and Associate Dean, School of Public Health, Tianjin Medical University, Tianjin, China

1995-2000 Associate Professor, School of Public Health, Tianjin Medical University, Tianjin, China

1989-1995 Assistant and Lecturer, School of Public Health, Tianjin Medical University, Tianjin, China


Project

1.Key Project of National Natural Science Foundation of China, No. 81730091, 3000,000 RMB, 2018-2022, Principal Investigator. Project Title: Effects of folate on the apoptosis of neurocytes and delaying cognitive decline by telomeres in older people.

2.National Natural Science Foundation of China, No. 81472967, 900,000RMB, 2015-2018, Principal Investigator. Project Title: Epigenetic effects of folic acid on brain development by DNA methylation.

3.Tianjin Science and Technology Support Program, No.15ZCZDSY01040, 300,000RMB, 2015-2018, Principal Investigator. Project Title: Intervention study of folic acid and vitamin B12 on the patients with Alzheimer’s disease in community.

4.Key Project of National Natural Science Foundation of China, No. 81130053, 2600,000 RMB, 2012-2016, Principal Investigator. Project Title: Epigenetic effects of folic acid on Alzheimer's disease by DNA methylation.

5.National Natural Science Foundation of China, No. 81072289, 330,000RMB, 2011-2013, Principal Investigator. Project Title: Epigenetic effects of folic acid on neural stem cells by DNA methylation.

6.National Natural Science Foundation of China, No. 30771797, 300,000RMB, 2008-2010, Principal Investigator. Project Title: Effects of folate on the proteomic profile of proliferation and differentiation of neural stem cells,

7.National Natural Science Foundation of China, No. 30571563, 260,000 RMB, 2006-2008, Principal Investigator. Project Title: Effective mechanisms of folate on the proliferation and differentiation of neural stem cells.

8.National Science and Technology Support Program, No. 2012BAI02B02, 950,000 RMB, 2012-2015, Principal Investigator. Project Title: Investigation of early intervention and prevention on obesity and type 2 diabetes in Chinese residents.

9.Key Project of Tianjin Natural Science Foundation, No.10JCZDJC18700, 200,000RMB, 2010-2013, Principal Investigator. Project Title: Effects of dietary intervention on metabolic syndrome.


Publication (as corresponding author)

1.Xinyan Wang, Wen Li, Zhenshu Li, Yue Ma, Jing Yan, John X. Wilson and Guowei Huang*. Maternal Folic Acid Supplementation During Pregnancy Promotes Neurogenesis and Synaptogenesis in Neonatal Rat Offspring. Cerebral Cortex. 2018 Aug 23. doi: 10.1093/cercor/bhy207. [Epub ahead of print].

2.Shanshan Cui, Xin Lv, Wen Li, Zhenshu Li, Huan Liu, Yuxia Gao*, Guowei Huang*. Folic acid modulates VPO1 DNA methylation levels and alleviates oxidative stress-induced apoptosis in vivo and in vitro. Redox Biology. 2018 Aug 8; 19:81-91.

3.Xinyan Wang, Wen Li, Shou Li, Jing Yan, John X. Wilson, Guowei Huang*.Maternal Folic Acid Supplementation During Pregnancy Improves Neurobehavioral Development in Rat Offspring. Mol Neurobiol. 2018, Mar 9, 55(3), 2676-2684.

4.Wen Li,Zhenshu Li,Shou Li,Xinyan Wang,John X. Wilson,Guowei Huang*. Periconceptional Folic Acid Supplementation Benefit to Development of Early Sensory-Motor Function through Increase DNA Methylation in Rat Offspring.Nutrients. 2018, 10(3), 292.

5.Ma F, Li Q, Zhou X, Zhao J, Song A, Li W, Liu H, Xu W, Huang G*.Effects of folic acid supplementation on cognitive function and Aβ-related biomarkers in mild cognitive impairment: a randomized controlled trial. Eur J Nutr. 2017 Dec 18. doi: 10.1007/s00394-017-1598-5. [Epub ahead of print]

6.Jing Yan, Yuyan Liu, Lujia Cao, Yuzhi Zheng, Wen Li, Guowei Huang*. Association between Duration of Maternal Folic Acid Supplementation and Postpartum Depression. Nutrients. 2017 Nov 2;9(11). pii: E1206.

7.Fei Ma, Tianfeng Wu, jiangang zhao, Lu Ji, Aili Song, Meilin Zhang, Guowei Huang*. Plasma Homocysteine and Serum Folate and Vitamin B12 Levels in Mild Cognitive Impairment and Alzheimer’s disease: A Case-control Study. Nutrients. 2017 Jul 8;9(7). pii: E725.

8.Shanshan Cui, Wen Li, Xin Lv, Pengyan Wang, Yuxia Gao*, Guowei Huang*. Folic Acid Supplementation Delays Atherosclerotic Lesion Development by Modulating MCP1 and VEGF DNA Methylation Levels In Vivo and In Vitro. Intl J Mol Sci. 2017 May 5;18(5): 990.

9.Fei Ma, Tianfeng Wu, Jiangang Zhao, Fengmei Han, Anna Marseglia, Huan Liu, Guowei Huang*. Effects of six-month folic acid supplementation on cognitive function and blood biomarkers in Mild Cognitive Impairment: a randomized controlled trial in China. J Gerontol A Biol Sci Med Sci.  2016 Oct;71(10):1376-83.

10.Wen Li, Huan Liu, Min Yua, Xumei Zhanga, Yan Zhangb, Hongbo Liub, John X. Wilsonc, Guowei Huang*.Folic acid alters methylation profile of JAK-STAT and long-term depression signaling pathways in Alzheimer's disease models. Mol Neurobiol. 2016 Nov;53(9):6548-6556.

11.Meilin Zhang, Li Zheng, Ping Li, Yufeng Zhu, Hong Chang, Xuan Wang, Weiqiao Liu, Yuwen Zhang, Guowei Huang*. 4-year trajectory of visceral adiposity index in the development of type 2 diabetes: a prospective cohort study. Ann Nutr Metab 2016;69:142-149.

12.Xuan Wang, Mingyue Zhang, Guang Lui, Hong Chang, Meilin Zhang, Wei Liu, Ziwei Li, Yixin Liu, Guowei Huang*. Associations of Serum Manganese Levels with Prediabetes and Diabetes among ≥60-Year-Old Chinese Adults: A Population-Based Cross-Sectional Analysis. Nutrients, 2016 Aug 13;8(8). pii: E497.

13.Hui Chen, Shuai Liu, Lu Ji, Tianfeng Wu, Yong Ji, Yuying Zhou, Miaoyan Zheng, Meilin Zhang, Weili Xu, Guowei Huang*. Folic acid supplementation mitigates Alzheimer’s disease by reducing inflammation: a randomized controlled trial.Mediators Inflamm. 2016;2016:5912146.

14.Huan Liu, Wen Li, Shijing Zhao, Xumei Zhang, Meilin Zhang, Yanyu Xiao, John X. Wilson, Guowei Huang*. Folic acid attenuates the effects of amyloid β oligomers on DNA methylation in neuronal cells. Eur J Nutr. 2016 Aug;55(5):1849-62.

15.Meilin Zhang, Ping Li, Yufeng Zhu, Hong Chang, Xuan Wang, Weiqiao Liu, Yuwen Zhang, Guowei Huang*. Higher visceral fat area increases the risk of vitamin D insufficiency and deficiency in Chinese adults. Nutrition & Metabolism. 2015 Nov 25;12:50.

16.Wen Li, Mingyue  Jiang, Shijing  Zhao, Huan  Liu, Xumei  Zhang, John  X Wilson, Guowei  Huang*. Folic Acid Inhibits Amyloid β-Peptide Production through Modulating DNA Methyltransferase Activity in N2a-APP Cells. Intl J Mol Sci. 2015 Oct 20, 16, 25002-25013.

17.Meilin Zhang, Yufeng Zhu, Ping Li, Hong Chang, Xuan Wang, Weiqiao Liu, Yuwen Zhang, Guowei  Huang*.Associations between Dietary Patterns and Impaired Fasting Glucose in Chinese Men: A Cross-Sectional Study. Nutrients. 2015 Sep 21;7(9):8072-89.

18.Huan Liu, Tian Tian, Shanchun Qin, Wen Li, Xumei Zhang, Xuan Wang, Yuxia Gao, Guowei Huang*. Folic acid deficiency enhances abeta accumulation in APP/PS1 mice brain and decreases amyloid-associated miRNAs expression. J Nutr Biochem. 2015 Dec; 26(12):1502-8.

19.Wen Li, Huan Liu, Min Yu, Xumei Zhang, Meilin Zhang, John X. Wilson, Guowei Huang*. Folic acid administration inhibits amyloid β-peptide accumulation in APP/PS1 transgenic mice. J Nutr Biochem. 2015 Aug, 26(8):883-891.IF: 4.4145-years IF: 4.669

20.Hui Chen,Shuai Liu, Lu Ji,Tianfeng Wu,Fei Ma,Yong Ji, Yuying Zhou, Miaoyan Zheng, Meilin Zhang, Guowei Huang*. Associations between Alzheimer’s Disease and Blood Homocysteine, Vitamin B12, and Folate: A Case-Control Study. Curr Alzheimer Res. 2015, 12(1):88-94.

21.Fei Ma, Tianfeng Wu, Rujuan Miao, Yan yu Xiao, Wenwen Zhang, Guowei Huang*. Conversion of Mild Cognitive Impairment to Dementia among Subjects with Diabetes: a Population-based Study of Incidence and Risk Factors with Five Years of Follow-up. J Alzheimers Dis. 2015,43(4):1441-1449.

22.Wen Li, Mingyue Jiang, Yanyu Xiao, Xumei Zhang, Shanshan Cui, Guowei Huang*. Folic acid inhibits tau phosphorylation through regulation of PP2A methylation in SH-SY5Y cells. J Nutr Health Aging. 2015 Feb;19(2):123-9.

23.Jing Yan, Lin Liu, Yun Zhu, Guowei Huang*, Peizhong Peter Wang*. The association between breastfeeding and childhood obesity: a meta-analysis. BMC Public Health 2014, 14:1267.


Postgraduate training

Graduated PhD 9 students

Graduated Master 40 students


Recruits students specialized

Nutrition and Food Hygiene


Membership of Academic Society

1.Teaching Instruction Committee of Preventive Medicine and Public Health of Ministry of Education, China, Member

2.Chinese Nutrition Association, Executive Director

3.Public Health Education Branch, Chinese Preventive Medicine Association, Executive Director

4.Tianjin Nutrition Association, Vice Chairman

5.Journal of Nutritional Biochemistry, Editorial Board

6.Asia Pacific Journal of Clinical Nutrition, Editorial Board

7.Acta Nutrimenta Sinica, Editorial Board

8.Chinese Journal of Preventive Medicine, Editorial Board